Publications by Date

PUBLICATIONS CHRONOLOGICAL
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*corresponding author

2019|2018|2017|2016| 2015 |2014 | 2013 | 2012| 2011| 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001| 2000

2019


  1. Acedo, J.; Bothwell, I.; An, L.; Trouth, A.; Frazier, C.; van der Donk, W.A.* “O-Methyltransferase-mediated Incorporation of a β-Amino Acid in Lanthipeptides” J. Am. Chem. Soc. 2019, 141, 16790-16801. PMCID: PMC6812601
  2. Howe, G.W.*; van der Donk, W.A.* “Temperature-independent kinetic isotope effects as evidence for a Marcus-like model of hydride tunneling in phosphite dehydrogenase” Biochemistry 2019, 58, 4260-4268. PMCID: PMC6852621
  3. Bothwell, I.R.; Cogan, D.P.; Kim, T.; Reinhardt, C.J.; van der Donk, W.A.*; Nair, S.K.* “Characterization of Glutamyl-tRNA Dependent Dehydratases using Non-Reactive Substrate Mimics” Proc. Natl. Acad. Sci. USA 2019, 35, 17245-17250. PMCID: PMC6717260
  4. Ting, C.P.; Funk, M.A.; Halaby, S.L.; Zhang, Z.; Gonen, T.; van der Donk, W.A.* “Use of a Scaffold Peptide in the Biosynthesis of Amino Acid Derived Natural Products” Science 2019, 365, 280-284. PMCID: PMC6686864
  5. Hegemann, J.D.; Shi, L.; Gross, M.L.*: van der Donk, W.A.* “Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases” ACS Chem. Biol. 2019, 14, 1583-1592. PMCID: PMC6642009
  6. Hegemann, J.D.; Bobeica, S.C.; Walker, M.C.; Bothwell, I.R.; van der Donk, W.A.* “Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications” ACS Synth. Biol. 2019, 8, 1204-1214. PMCID: PMC6525029
  7. Funk, M.A.; Ting, C.; van der Donk, W.A.* “Catalytic Use of a Leader Peptide in the Biosynthesis of 3-Thia-glutamate” http://biorxiv.org/cgi/content/short/338681v1. DOI: 10.1101/338681.
  8. Bobeica, S.C.; Dong, S.-H.; Huo, L.; 1, Mazo, N.; McLaughlin, M.I.; Jiménez-Osés, G.; Nair, S.K.*; van der Donk, W.A.* “Insights into AMS/PCAT Transporters from Biochemical and Structural Characterization of a Double Glycine Motif Protease” eLife, 2019; 8, e42305. PMCID: PMC6363468
  9. Wu, C.; Biswas, S.; Garcia De Gonzalo, C.V.; van der Donk, W.A* “Investigations into the mechanism of action of sublancin” ACS Infect. Dis. 2019, 5, 454-459. PMCID: PMC6408254
  10. Tang, W.; Bobeica, S.C.; Wang, L.; van der Donk* “CylA is a Sequence-Specific Protease Involved in Toxin Biosynthesis” J. Ind. Microbiol. Biotechnol. 2019, 46, 537-549. PMCID: PMC6450559
  11. Bougioukou, D.J.; Ting, C.P.; Peck, S.C.; Mukherjee, S.; van der Donk, W.A.* “Use of the Dehydrophos Biosynthetic Enzymes to Prepare Antimicrobial Analogs of Alaphosphin” Org. Biomol. Chem. 2019, 17, 822-829. PMCID: PMC6344287

2018


  1. Howe, G.W.; van der Donk, W.A.* “18O Kinetic Isotope Effects Reveal an Associative Transition State for Phosphite Dehydrogenase Catalyzed Phosphoryl Transfer” JACS 2018, 140, 17820-17824. NIHMSID: 1001347
  2. Ren H.; Biswas, S.; Ho, S.; van der Donk, W.A.*; Zhao, H.* “Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli” ACS Chem. Biol. 2018, 13, 2966-2972.
  3. Si, T.; Tian, Q.; Min, Y.; Zhang, L.; Sweedler, J.; van der Donk, W.A.*; Zhao, H.* “Rapid structure-activity screening of lanthipeptide analogs via in-colony removal of leader peptides in Escherichia coli” J. Am. Chem. Soc. 2018, 140, 11884-11888NIHMS ID:1021119
  4. Wang, K.K.A.; Ng, T.L.; Wang, P.; Huang, Z.; Balskus, E.P.*, van der Donk, W.A.* “Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kanamycin” Nat. Comm. 2018, 9, 3687. PMCID: PMC6133997
  5. An, L.; Cogan, D.P.; Navo, C.D.; Jiménez-Osés, G.; Nair, S.K.*; van der Donk, W.A.* “Substrate-assisted Enzymatic Formation of Lysinoalanine in Duramycin” Nat. Chem. Biol. 2018, 14, 28-933. PMCID: PMC6372306
  6. Dutta, D.; Lai, K.-Y.; Reyes-Ordoñez, A.; Chen, J.; van der Donk, W.A* “Lanthionine Synthetase C-like Protein 2 (LanCL2) is Important for Adipogenic Differentiation” J. Lipid Res. 2018, 8, 1433-1445. PMCID: PMC6071776
  7. McLaughlin, M.I.; van der Donk, W.A.* “Stereospecific Radical-mediated B12-dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3” Biochemistry 2018, 57, 4967-4971. PMCID: PMC6103835
  8. Hegemann, J.D.; Schwalen, C.J.; Mitchell, D.A.*; van der Donk, W.A.* “Elucidation of the Roles of Conserved Residues in the Biosynthesis of the Lasso Peptide Paeninodin” Chem. Comm. 2018, 54, 9007-9010. PMCID: PMC6092944
  9. Bobeica, S.C.; van der Donk, W.A.* “The Enzymology of Prochlorosin Biosynthesis” Methods Enzymol. 2018, 604, 165-203.
  10. Hegemann, J.D.; van der Donk, W.A.* “Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems” J. Am. Chem. Soc. 2018, 140, 5743-5754. PMCID: PMC5932250
  11. Kakkar, N.; Perez, J.; Liu, W.R.; Jewett, M.; van der Donk, W.A.* “Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics” ACS Chem. Biol. 2018, 20, 951-957. PMCID: PMC5910287
  12. Hetrick, K.J.; Walker, M.C; van der Donk, W.A.* “Development and Application of Yeast and Phage Display of Diverse Lanthipeptides” ACS Cent. Sci. 2018, 4, 458–467.  PMCID: PMC5920614
  13. Koehnke, J.; Naismith, J.; van der Donk, W. A., Cyclic Peptides: from Bioorganic Synthesis to Applications. Royal Society of Chemistry: Cambridge, UK, 2018.
  14. Ulrich, E.C.; Bougioukou, D.J.; van der Donk, W.A.* “Investigation of Amide Bond Formation during Dehydrophos Biosynthesis” ACS Chem. Biol. 2018, 13, 537-541. PMCID: PMC5856630
  15. Yang, X.; Lennard, K.R.: He, C.; Walker, M.C.; Ball, A.T.; Doigneaux, C.; Tavassoli, A.*; van der Donk, W.A.* “A lanthipeptide library used to identify inhibitors of a protein-protein interaction” Nat. Chem. Biol. 2018, 14, 375-380. PMCID: PMC5866752
  16. Repka, L.M.; Hetrick, K.J.; Chee, S.H.; van der Donk, W.A.* “Characterization of Leader Peptide Binding during Catalysis by the Nisin Dehydratase NisB” J. Am. Chem. Soc. 2018, 140, 4200-4203. PMCID: PMC5901694

2017


  1. Zhang, Z.; Mahanta, N.; Hudson, G.A.; Mitchell, D.A.*; van der Donk, W.A.* “Mechanism of a Class C Radical S-Adenosyl-L-methionine Thiazole Methyl Transferase” J. Am. Chem. Soc. 2017, 139, 18623-18631. PMCID: PMC5748327
  2. Biswas, S.; Garcia De Gonzalo, C.V.; Repka, L.M.; van der Donk, W.A.* “Structure Activity Relationships of the S-linked Glycocin Sublancin” ACS Chem. Biol. 2017, 12, 2965-2969. PMCID: PMC5732038
  3. Cogan, D.P.; Hudson, G.A.; Zhang, Z.; Pogorelov, T.V.; van der Donk, W.A.; Mitchell, D.A.; Nair, S.K.* “Mechanism of Enzymatic [4+2]-Aza-cycloaddition in Thiopeptide Antibiotic Biosynthesis” Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 12928-12933. PMCID: PMC5724283
  4. Born, D.A.; Ulrich, E.C.; Ju, K.-S.; Peck, S.C.; van der Donk, W.A.*; Drennan, C.L.* “Structural Basis for Methylphosphonate Biosynthesis” Science 2017, 358, 1336-1339. PMCID: PMC5901744
  5. Funk, M.; van der Donk, W.A.* “Ribosomal Natural Products, Tailored to Fit” Acc. Chem. Res. 2017, 50, 1577-1586. PMCID: PMC5603336
  6. Cubillos-Ruiz, A.; Berta-Thompson, J.W.; Becker, J.W.; van der Donk, W.A.; Chisholm, S.W.* “Evolutionary Radiation of Lanthipeptides in Marine Cyanobacteria” Proc. Natl. Acad. Sci. U.S.A. 2017, 114, E5424-E5433. PMCID: PMC5502607
  7. Burkhart, B.; Kakkar, N.; Hudson, G.; van der Donk, W.A.*; Mitchell, D.A.* “Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products” ACS Cent. Sci. 2017, 3, 629-638. PMCID: PMC5492250
  8. Repka, L.M.; Chekan, J.R.; Satish K. Nair, S.K.*; van der Donk, W.A.* “Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes” Chem. Rev. 2017, 117, 5457-5520. PMCID: PMC5408752
  9. Mahanta, N.; Zhang, Z.; Hudson, G.A.; van der Donk, W.A.;* Mitchell, D.A.* “Reconstitution and substrate specificity of the radical S-Adenosyl-methionine thiazole C-methyltransferase in thiomuracin biosynthesis” J. Am. Chem. Soc. 2017, 139, 4310-4313. PMCID:PMC5477235
  10. Hetrick, K.J.; van der Donk, W.A.* “Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era” Curr. Opin. Chem. Biol. 2017, 38, 36-44. PMCID: PMC5474203
  11. Peck, S.C.; van der Donk, W.A.* “Go It Alone: Four Electron Oxidations by Mononuclear Non‐heme Iron Enzymes” J. Biol. Inorg. Chem. 2017, 22, 381-394. PMCID:PMC5352498
  12. Ortega, M.A.; Cogan, D.P.; Mukherjee, S.; Garg, N.; Li, B.; Maffioli, S.; Donadio, S.; Sosio, M.; Escano, J.; Smith, J.L.; Nair, S.K.*; van der Donk, W.A.* “Two flavoenzymes catalyze the post-translational generation of 5-chlorotryptophan and 2-aminovinyl-cysteine during NAI-107 biosynthesis” ACS Chem. Biol. 2017, 12, 548-557. PMCID: PMC5315687
  13. Olivares, P.; Ulrich, E.C.; Chekan, J.R.; van der Donk, W.A.*; Nair, S.K.* “Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads” ACS Chem. Biol. 2017, 12, 456-463. PMCID: PMC5315633
  14. Peck, S.C.; Wang, C.; Dassama, L.M.K.; Zhang, B.; Guo, Y.; Rajakovich, L.J.; Bollinger, J.M.*; Krebs, C.*; van der Donk, W.A.* “O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase” J. Am. Chem. Soc. 2017, 139, 2045-2052. PMCID: PMC5302023
  15. He, C.; Zeng, M.; Dutta, D.; Hee Koh, T.H.; Chen, J.*; van der Donk, W.A.* “LanCL proteins are not Involved in Lanthionine Synthesis in Mammals” Sci. Rep. 2017, 7, 40980. PMCID: PMC5247676
  16. Huo, L.; Okesli, A.; Zhao, M.; van der Donk, W.A.* “Insights into the biosynthesis of duramycin” Appl. Environ. Microbiol. 2017, 83, e02698-16. PMCID: PMC5244291
  17. Clark, K.M.; Tiang, S.; van der Donk, W.A.*; Lu, Y.* “Probing the Role of Backbone Carbonyl Interaction with the CuA Center in Azurin by Replacing the Peptide Bond with an Ester Linkage” Chem. Comm. 2017, 53, 224-227. PMCID: PMC5253137

2016


  1. Mukherjee, S.; Huo, L.; Thibodeaux, G.; van der Donk, W.A.* “Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin” Org. Lett. 2016, 18, 6188-6191. PMCID: PMC5269379
  2. Zhang, Z.; Hudson, G.A.; Mahanta, N.; Tietz, J.I.; van der Donk, W.A.*; Mitchell, D.A.* “Biosynthetic timing and substrate specificity for the thiopeptide thiomuracin” J. Am. Chem. Soc. 2016, 138, 15511-15514. PMCID: PMC5148741
  3. Ulrich, E.C.; van der Donk, W.A.* “Cameo appearances of aminoacyl-tRNA in natural product biosynthesis” Curr. Opin. Chem. Biol., 2016, 35, 29-36. PMCID: PMC5161580
  4. Tang, W.; Thibodeaux, G.N.; van der Donk, W.A.* “The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis” ACS Chem. Biol. 2016, 11, 2438-2446. PMCID: PMC5289929
  5. Thibodeaux, C.J.; Wagoner, J.; Yu, Y.; van der Donk, W.A.* “Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis” J. Am. Chem. Soc. 2016, 138, 6436-6444. PMCID: PMC4880487
  6. Huo, L.; van der Donk, W.A.* “Discovery and characterization of bicereucin, an unusual D-amino acid-containing mixed two-component lantibiotic” J. Am. Chem. Soc. 2016, 138, 5254-5257. PMCID: PMC4851115
  7. Huang, Z.; Wang, K.-K.A.; van der Donk, W.A.* “New Insights into the Biosynthesis of Fosfazinomycin” Chem. Sci. 2016, 7, 5219-5223. PMCID: PMC5215806
  8. Garg, N.; Goto, Y.; Chen, T.; van der Donk, W.A.* “Characterization of the stereochemical configuration of lanthionine formation by the lanthipeptide synthetase GeoM” Biopolymers Pept. Sci. 2016, 106, 834–842. PMCID: PMC5108700
  9. Ortega, M. A.; van der Donk, W.A.* “New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products” Cell Chem. Biol. 2016, 23, 31-44. PMCID: PMC4779184
  10. Ding, W.; Liu, W.-Q.; Jia, Y.; Li, Y.; van der Donk, W.A.*; Zhang, Q.* “Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes” Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 3521-3526. PMCID: PMC4822579
  11. Ortega, M.A.; Hao, Y.; Walker, M.C.; Donadio, S.; Sosio, M.; Nair, S.K.;* van der Donk, W.A.* “Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis” Cell Chem. Biol. 2016, 23, 370-380. PMCID: PMC4798866
  12. Zhao, X.; van der Donk, W.A.* “Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium” Cell Chem. Biol. 2016, 23, 246-256. PMCID: PMC4814930

2015


  1. Hudson, G.; Zhang, Z.; Tietz, J.; Mitchell, D.A.*; van der Donk, W.A.* “In vitro biosynthesis of the core scaffold of the thiopeptide thiomuracinJ. Am. Chem. Soc. 2015, 137, 16012-16015. PMCID: PMC4819586
  2. Yang, X.: van der Donk, W.A.* “Posttranslational introduction of D-alanine into ribosomally synthesized peptides by the dehydroalanine reductase NpnJ” J. Am. Chem. Soc. 2015, 137, 12426-12429. PMCID: PMC4599312
  3. Tang, W.; Dong, S.-H.; Repka, L.M.; He, C.; Nair, S.K.*; van der Donk, W.A.* “Applications of the Class II Lanthipeptide Protease LicP for Sequence-Specific, Traceless Peptide Bond Cleavage” Chem. Sci. 2015, 6, 6270-6279. PMCID: PMC5289929
  4. Garcia De Gonzalo, C.V.; Denham, E.L.; Mars, R.A.T.; Stülke, J.; van der Donk, W.A.*; van Dijl, J.M.* “The Phosphoenolpyruvate:Sugar Phosphotransferase system is involved in sensitivity to the glucosylated bacteriocin sublancin” Antimicrob. Agents Chemother. 2015, 59, 6844-6854. PMCID: PMC4604375
  5. Medema, M.H.*; Kottmann, R.; Yilmaz, P.; Cummings, M.; Biggins, J.B.; Blin, K.; de Bruijn, I.; Chooi. Y.H.; Claesen, J.; Coates, R.C.; Cruz-Morales, P.; Duddela, S.; Düsterhus, S.; Edwards, D.J.; Fewer, D.P.; Garg, N.; Geiger, C.; Gomez-Escribano, J.P.; Greule, A.; Hadjithomas, M.; Haines, A.S.; Helfrich, E.J.; Hillwig, M.L.; Ishida, K.; Jones, A.C.; Jones, C.S.; Jungmann, K.; Kegler, C.; Kim, H.U.; Kötter, P.; Krug, D.; Masschelein, J.; Melnik, A.V.; Mantovani, S.M.; Monroe, E.A.; Moore, M.; Moss, N.; Nützmann, H.W.; Pan, G.; Pati, A.; Petras, D; Reen, F.J.; Rosconi, F.; Rui, Z.; Tian, Z.; Tobias, N.J.; Tsunematsu, Y.; Wiemann, P.; Wyckoff, E.; Yan, X.; Yim, G.; Yu, F.; Xie, Y.; Aigle, B.; Apel, A.K.; Balibar, C.J.; Balskus, E.P.; Barona-Gómez, F.; Bechthold, A.; Bode, H.B.; Borriss, R.; Brady, S.F.; Brakhage, A.A.; Caffrey, P.; Cheng, Y.Q.; Clardy, J.; Cox, R.J.; De Mot, R.; Donadio, S.; Donia, M.S.; van der Donk, W.A.; Dorrestein, P.C.; Doyle, S.; Driessen, A.J.; Ehling-Schulz, M.; Entian, K.D.; Fischbach, M.A.; Gerwick, L.; Gerwick, W.H.; Gross, H.; Gust, B.; Hertweck, C.; Höfte, M.; Jensen, S.E.; Ju, J.; Katz, L.; Kaysser, L.; Klassen, J.L.; Keller, N.P.; Kormanec, J.; Kuipers, O.P.; Kuzuyama, T.; Kyrpides, N.C.; Kwon, H.J.; Lautru, S.; Lavigne, R.; Lee, C.Y.; Linquan, B.; Liu, X.; Liu, W.; Luzhetskyy, A.; Mahmud, T.; Mast, Y.; Méndez, C.; Metsä-Ketelä, M.; Micklefield, J.; Mitchell, D.A.; Moore,  B.S.; Moreira, L.M.; Müller, R.; Neilan, B.A.; Nett, M.; Nielsen, J.; O’Gara, F.; Oikawa, H.; Osbourn, A.; Osburne, M.S.; Ostash, B.; Payne, S.M.; Pernodet, J.L.; Petricek, M.; Piel, J.; Ploux,  O.; Raaijmakers, J.M.; Salas, J.A.; Schmitt, E.K.; Scott, B.; Seipke, R.F.; Shen, B.; Sherman, D.H.; Sivonen, K.; Smanski, M.J.; Sosio, M.; Stegmann, E.; Süssmuth, R.D.; Tahlan, K.; Thomas, C.M.; Tang, Y.; Truman, A.W.; Viaud, M.; Walton, J.D.; Walsh, C.T.; Weber, T.; van Wezel, G.P.; Wilkinson, B.; Willey, J.M.; Wohlleben, W.; Wright, G.D.; Ziemert, N.; Zhang, C.; Zotchev, S.B.;  Breitling, R.; Takano, E.; Glöckner, F.O. “Minimum Information about a Biosynthetic Gene cluster” Nat. Chem. Biol. 2015, 11, 625-631.
  6. Walker, M.; van der Donk, W.A.* “The Many Roles of Glutamate in Metabolism” J. Ind. Microbiol. Biotechnol. 2015, 43, 419-430. PMCID: PMC4753154
  7. Zhu, H.; Peck, S.C.; Bonnot, F.; van der Donk, W.A.; Klinman, J.P.* “Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species” J. Am. Chem. Soc. 2015, 137, 10448-10451. PMCID: PMC4970508
  8. Huang, Z.; van der Donk, W.A.* “An Unexpected Role for Ergothioneine” National Science Review 2015, 2, 382-383.
  9. Dong, S.-H.; Tang, W.; Lukk, T.; Nair, S.K.*; van der Donk, W.A.* “The Enterococcal Cytolysin Synthetase Has an Unanticipated Lipid Kinase Fold” eLife 2015, 4:e07607. PMCID: PMC4550811
  10. Ju, K.-S.; Gao, J.; Doroghazi, J.R.; Wang, K.K.A; Thibodeaux, C.J.; Li, S.; Metzger, E.; Fudala, J.; Su, J.; Zhang, J.; Lee, J.; Cioni, J.P.; Evans, B.S.; Hirota, R.; Labeda, D.P.; van der Donk, W.A.*; Metcalf, W.W.* “Discovery of Phosphonic Acid Natural Products by Genome Mining of 10,000 Actinomycetes” Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 12175-12180. PMCID: PMC4593130
  11. Bindman, N.A.; Bobeica, S.; Liu, W.R*; van der Donk, W.A.* “Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid” J. Am. Chem. Soc. 2015, 137, 6975-6978. PMCID: PMC4505723
  12. van der Donk, W.A. “Bacteria Do It Differently: An Alternative Path to Squalene” ACS Cent. Sci. 2015, 1, 64-65. PMCID: PMC4827487
  13. Zhang, Q.; Doroghazi, J.R.; Zhao, X.; Walker, M.C.; van der Donk, W.A.* “Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in Actinobacteria
    Appl. Environ. Microbiol. 2015, 81, 4339-4350. PMCID: PMC4475899
  14. Yu, Y.; Mukherjee, S.; van der Donk, W.A.* “Product Formation by the Promiscuous Lanthipeptide Synthetase ProcM is under Kinetic Control” J. Am. Chem. Soc. 2015, 137, 5140-5148. PMCID: PMC4487812
  15. Yang, X.; van der Donk, W.A.* “The Michael-type cyclizations in lantibiotic biosynthesis are reversible” ACS Chem. Biol. 2015, 10, 1234-1238. PMCID: PMC4433588
  16. Peck, S.C.; Chekan, J.R.; Ulrich E.C.; Nair, S.K.; van der Donk, W.A.* “A Common Late-Stage Intermediate in Catalysis by 2-Hydroxyethyl-phosphonate Dioxygenase and Methylphosphonate Synthase” J. Am. Chem. Soc. 2015, 137, 3217-3220. PMCID: PMC4487810
  17. Thibodeaux, G.N.; McClerren, A.L.; Ma, Y.; Gancayco, M.R.; van der Donk, W.A.* “Synergistic binding of the leader and core peptide by the lantibiotic synthetase HalM2” ACS Chem. Biol. 2015, 10, 970-977. PMCID: PMC4414810
  18. Huang, Z.; Wang, K.-K.A.; Lee, J.; van der Donk, W.A.* “Biosynthesis of fosfazinomycin is a convergent process” Chem. Sci. 2015, 6, 1282-1287. PMCID: PMC4303578
  19. Tang, W.; Jimenez-Oses, G.; Houk, K.N.*; van der Donk, W.A.* “Substrate Control in Stereoselective Lanthionine Biosynthesis” Nat. Chem. 2015, 7, 57-64. PMCID: PMC4270103
  20. Ortega, M.A.; Hao, Y.; Zhang, Q.; Walker, M.C.; van der Donk, W.A.*, Nair, S.K.* “Structure and Mechanism of the tRNA-Dependent Lantibiotic Dehydratase NisB” Nature, 2015, 517, 509-512. PMCID: PMC4430201

2014


  1. Thibodeaux, C.; Ha, T.; van der Donk, W.A.* “A Price to Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases, ProcM and HalM2” J. Am. Chem. Soc., 2014, 136, 17513-17529. PMCID: PMC4277782
  2. Zeng, M.; van der Donk, W.A.*; Chen, J.* “Lantibiotic C-like protein 2 (LanCL2) is a novel regulator of Akt” Mol. Biol. Cell, 2014, 25, 3954-3961. PMCID: PMC4244203
  3. van der Donk, W.A.*; Nair, S.K.* “Structure and Mechanism of Lanthipeptide Biosynthetic Enzymes” Curr. Opin. Struct. Biol. 2014, 29, 58-66. PMCID: PMC4267917
  4. Zhang, Q.; Yang, X.; Wang, H.; van der Donk, W.A.* “High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis” ACS Chem. Biol. 2014, 2686-2694. PMCID: PMC4245175
  5. Huang, Y.; Reis, E.S.; Knerr, P.J.; van der Donk, W.A.; Ricklin, D.; Lambris, J.D.* “Conjugation to Albumin-Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin” ChemMedChem 2014, 9, 2223-2226. PMCID: PMC4177305
  6. Zhang, Q.; Ortega, M.A.; Shi, Y.; Wang, H.; Melby, J.O.; Tang, W.; Mitchell, D.A.; van der Donk, W.A.* “Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS” Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 12031-12036. PMCID: PMC4143002
  7. Mukherjee, S.; van der Donk, W.A.* “Mechanistic Studies on the Substrate-Tolerant Lanthipeptide Synthetase ProcM” J. Am. Chem. Soc. 2014, 136, 10450-10459. PMCID: PMC4111213
  8. Ortega, M.A.; Velásquez, J.E.; Garg, N.; Zhang, Q.; Joyce, R.E.; Nair, S.K.*; van der Donk, W.A.* “Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO” ACS Chem. Biol., 2014, 9, 1718-1725. PMCID: PMC4136673
  9. Bindman, N. A; van der Donk, W.A.* RiPPs: Ribosomally Synthesized and Posttranslationally Modified Peptides. In Natural Products: Discourse, Diversity, and Design; Osbourn, A., Goss, R., Carter, G.T., Eds.; John Wiley & Sons, Inc.: Hoboken, NJ, USA, 2014; pp 197-217.
  10. Ranaghan, K.E.; Hung, J.E.; Bartlett, G.J.; Mooibroek, T.J.; Harvey, J.N.; Woolfson, D.N.; van der Donk, W.A.*; Mulholland, A.J.* “A catalytic role for methionine revealed by a combination of computation and experiments on phosphite dehydrogenase” Chem. Sci. 2014, 5, 2191-2199.
  11. Clark, K.M.; Yu, Y.; van der Donk, W.A.*; Blackburn, N.J.; Lu, Y.* “Modulating the Copper-Sulfur Interaction in Type 1 Blue Copper Azurin by Replacing Cys112 with Nonproteinogenic Homocysteine” Inorg. Chem. Front., 2014, 1, 153-158. PMCID: PMC3972132
  12. Garcia De Gonzalo, C.V.; Zhu, L; Oman, T.J.; van der Donk, W.A.* “NMR structure of the S-linked glycopeptide sublancin 168” ACS Chem. Biol. 2014, 9, 796–801. PMCID: PMC3985867
  13. Hung, J.; Fogle, E.J.; Garg, N.; Chekan, J.R.; Nair, S.K.; van der Donk, W.A.* “Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase” PLoS One 2014, 9, e87134. PMCID: PMC3909101
  14. Wang, H.; Oman, T.J.; Zhang, R.; Garcia De Gonzalo, C.V.; Zhang, Q.; van der Donk, W.A.* “The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O– and S-glycosylation” J. Am. Chem. Soc. 2014, 136, 84-87. PMCID: PMC3913795
  15. Gao, J.; Ju, K.S.; Yu, X.; Velásquez, J.E.; Mukherjee, S.; Lee, J.; Zhao, C.; Evans, B.S.; Doroghazi, J.R.; Metcalf, W.W.*; van der Donk, W.A.* “Use of a Phosphonate Methyltransferase in the Identification of the Fosfazinomycin Biosynthetic Gene Cluster” Angew. Chem. Intl. Ed. 2014, 53, 1334-1337. PMCID: PMC3927463
  16. Agarwal, V.A.; Peck, S.C.; Chen, J-H.; Borisova, S.A.; Chekan, J.R.; van der Donk, W.A.*; Nair, S.K.* “Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate biodegradation” Chem. Biol. 2014, 21, 125-135. PMCID: PMC4313731
  17. Garg, N.; Oman, T.J.; Wang, T.-S. A.; Garcia De Gonzalo, C.V.; Walker, S.; van der Donk, W.A.* “Mode of Action and Structure-Activity Relationship Studies of Geobacillin I” J. Antibiot. 2014, 67, 133-136. special issue in honor of Christopher T. Walsh. PMCID: PMC4004768

2013


  1. Yu, Y.; Zhang, Q.; van der Donk, W.A.* “Insights into the Evolution of Lanthipeptide Biosynthesis” Protein Sci. 2013, 22, 1478-1489. Invited review for receiving the Kaiser award. PMCID: PMC3831664
  2. Peck, S.P; van der Donk, W.A.* “Phosphonate Biosynthesis and Catabolism: A Treasure Trove of Unusual Enzymology” Curr. Opin. Chem. Biol. 2013, 17, 580-588. PMCID: PMC3764496
  3. Bindman, N. A; van der Donk, W.A.* “A General Method for Fluorescent Labeling of the N-Termini of Lanthipeptides and Its Application to Visualize their Cellular Localization” J. Am. Chem. Soc. 2013, 135, 10362–10371. PMCID: PMC3775354
  4. Bougioukou, D.J.; Mukherjee, S.; van der Donk, W.A.* “Revisiting the Biosynthesis of Dehydrophos Reveals a tRNA Dependent Pathway” Proc. Natl. Acad. Sci. USA 2013, 110, 10952-10957. PMCID: PMC3704017
  5. Knerr, P.J.; van der Donk, W.A.* “Chemical Synthesis of the Lantibiotic Lacticin 481 Reveals the Importance of Lanthionine Stereochemistry” J. Am. Chem. Soc. 2013, 135, 7094-7097. PMCID: PMC3736828
  6. Peck, S.C.; van der Donk, W.A.* “Biochemistry: Positive and Radical” Nature 2013, 496, 34-35. Commentary.
  7. Evans, B.S.*; Zhao, C.; Gao, J.; Evans, C.M.; Ju, K.S.; Doroghazi, J.R.; van der Donk, W.A.; Kelleher, N.L.; Metcalf, W.W. “Discovery of the Antibiotic Phosacetamycin via a New Mass Spectrometry-Based Method for Phosphonic Acid Detection” ACS Chem. Biol. 2013, 8, 908-913. PMCID: PMC3657337
  8. Garg, N.; Salazar-Ocampo, L.M.A.; van der Donk, W.A.* “In vitro activity of the Nisin Dehydratase NisB” Proc. Natl. Acad. Sci. USA 2013, 110, 7258-7263. PMCID: PMC3645518
  9. Yang, X.; van der Donk, W.A.* “Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products: New Insights Into the Role of Leader and Core Peptides During Biosynthesis” Chem. Eur. J. 2013, 24, 7662-7677. PMCID: PMC3838977
  10. Tang, W.; van der Donk, W.A.*The Sequence of the Enterococcal Cytolysin Imparts Unusual Lanthionine Stereochemistry” Nat. Chem. Biol. 2013, 9, 157-159. PMCID: PMC3578037
  11. Arnison, P. et al.; van der Donk, W.A.* “Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products: Overview and Recommendations for a Universal Nomenclature” Nat. Prod. Rep. 2013, 30, 108-160. PMCID: PMC3954855

2012


  1. Thibodeaux, C. J.; van der Donk, W.A.* “Converging on a mechanism for choline degradation” Proc. Natl. Acad. Sci. U.S.A., 2012, 52, 21184–21185. PMCID: PMC3535664
  2. Zhang, Q.; Yu, Y.; Vélasquez, J. E.; van der Donk, W. A.* “Evolution of Lanthipeptide Synthetases” Proc. Natl. Acad. Sci. U.S.A., 2012, 109, 18361-18366. PMCID: PMC3494888
  3. Shi, Y.: Bueno, A; van der Donk, W.A.* “Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coliChem. Comm. 2012, 48, 10966-10968. PMCID: PMC3485686
  4. Cooke, H.A.; Peck, S.C.; Evans, B.S.; van der Donk, W.A.* “Mechanistic Investigation of Methylphosphonate Synthase, a Non-Heme Iron-Dependent Oxygenase” J. Am.Chem. Soc., 2012, 134, 15660-15663. PMCID: PMC3458437
  5. Thibodeaux, G.; van der Donk, W.A.* “An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase” Chem. Comm. 2012, 48, 10615-10617. PMCID: PMC3475617
  6. Knerr, P.J.; Oman, T.J.; Garcia de Gonzalo, C.; Lupoli,T.J. Walker S.; van der Donk, W. A.* “Non-Proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation” ACS Chem. Biol. 2012, 7, 1791-1795. PMCID: PMC3501146
  7. Zhang, Q.; van der Donk, W.A.* “Catalytic promiscuity of a bacterial α-N-methyltransferase” FEBS Lett. 2012, 588, 3391-3397. PMCID: PMC3462432
  8. Metcalf, W.W.*; Griffin, B.M.; Cicchillo, R.M.; Gao, J.; Janga, S.C.; Cooke, H.A.; Circello, B.T.; Evans; B.S.; Martens-Habbena, W.; Stahl, D.A.; van der Donk, W.A.* “Synthesis of methylphosphonic acid by abundant marine microbes: a source for methane in the aerobic ocean” Science 2012, 337, 1104-1107. PMCID: PMC3466329
  9. Wang, H.; van der Donk, W.A.* “Biosynthesis of the Class III Lantipeptide Catenulipeptin” ACS Chem. Biol. 2012, 7, 1529-1535. PMCID: PMC3448297
  10. Peck, S.C.; Gao, J.; van der Donk, W.A.* “Discovery and Biosynthesis of Phosphonate and Phosphinate Natural Products” Methods Enzymol. 2012, 516, 101-123 (special volume on natural product biosynthesis edited by Sir David Hopwood).
  11. Zou, Y.; Zhang, H.; Brunzelle, J.S.; Johannes, T.W.; Woodyer, R.; Hung, J.E.; Nair, N.; van der Donk, W.A.; Zhao, H.; Nair, S.K.* “Crystal Structures of Phosphite Dehydrogenase Provide Insights into Nicotinamide Cofactor Regeneration” Biochemistry 2012, 51, 4263-4270.
  12. Kim, S.Y.; Ju, K.-S.; Metcalf, W.W.; Evans, B.S.; Kuzuyama, T.; van der Donk, W.A.* “Different Biosynthetic Pathways to Fosfomycin in Pseudomonas syringae and Streptomyces” Antimicrob. Agents Chemother. 2012, 56, 4175-4183. PMCID: PMC3421606
  13. Knerr, P.J.; van der Donk, W. A.* “Chemical Synthesis and Biological Activity of Analogues of the Lantibiotic Epilancin 15X” J. Am. Chem. Soc. 2012, 134, 7648-7651. PMCID: PMC3349288
  14. Hung, J.E.; Fogle, E.J.; Christman, H.D.; Johannes, T.W.; Zhao, H.; Metcalf, W.W.; van der Donk, W.A.* “Investigation of the Role of Arg301 Identified in the X-ray Structure of Phosphite Dehydrogenase” Biochemistry 2012, 51, 4254-4262. PMCID: PMC3361975
  15. Tang, W.; van der Donk, W. A.* “Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria” Biochemistry 2012, 51, 4271-4279. PMCID: PMC3361976
  16. Garg, N.; Tang, W.; Goto, Y.; van der Donk, W.A.* “Lantibiotics from Geobacillus thermodenitrificansProc. Natl. Acad. Sci. U.S.A. 2012, 109, 5241-5246. PMCID: PMC3325677
  17. Oman, T.J.; Knerr, P.J.; Bindman, N.A.; Velásquez, J.E.; van der Donk, W.A.* “An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate” J. Am. Chem. Soc. 2012, 134, 6952-6955. PMCID: PMC3350211
  18. Knerr, P.J.; van der Donk, W.A.* “Discovery, Biosynthesis and Engineering of Lantipeptides” Ann. Rev. Biochem. 2012, 81, 479-505.
  19. Peck, S.C.; Kim, S.Y.; Evans, B.S.; van der Donk, W.A.* “Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis” Med. Chem.     Commun. 2012, 3, 967-970. PMCID: PMC3764496
  20. Zhang, Q.; van der Donk, W.A.* “Answers to the carbon-phosphorus lyase conundrum” ChemBioChem 2012, 13, 627-629. PMCID: PMC3206492

2011


  1. Zhang, Q.; van der Donk, W.A.*; Liu, W.* “Radical-mediated enzymatic methylation: a tale of two SAMs” Acc. Chem. Res. 2011, 45, 555-564. PMCID: PMC3328197
  2. Oman, T.O.; Lupoli, T.J.; Wang, T-S. A.; Kahne, D.; Walker, S.*; van der Donk, W.A.* “Haloduracin a Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry” J. Am. Chem. Soc. 2011, 133, 17544-17547. PMCID: PMC3206492
  3. Agarwal, V.; Borisova, S.A.; Metcalf, W.W.; van der Donk, W.A.*; Nair, S.K. * “Structural and Mechanistic Insights into C-P Bond Hydrolysis by Phosphonoacetate Hydrolase” Chem. Biol. 2011, 18, 1230-1240. PMCID: PMC4321816
  4. Wang, H.; van der Donk, W.A.* “Substrate selectivity of the S-glycosyltransferase from sublancin biosynthesis” J. Am. Chem. Soc. 2011, 133, 16394–16397. PMCID: PMC3191765
  5. DeSieno, M.A.; van der Donk, W.A.; Zhao, H.* “Characterization and Application of the Fe(II) and α-Ketoglutarate Dependent Hydroxylase FrbJ” Chem. Comm. 2011, 47, 10025-10027. PMCID: PMC4091617
  6. Velásquez, J.E.; Zhang, X.; van der Donk, W.A.* “Biosynthesis of the Antimicrobial Peptide Epilancin 15X and its Unusual N-terminal Lactate Moiety” Chem. Biol. 2011, 18, 857-867. PMCID: PMC3161514
  7. Okesli, A.; Cooper, L.E.; Fogle, E.J.; van der Donk, W.A.* “Nine Posttranslational Modifications During the Biosynthesis of Cinnamycin” J. Am. Chem. Soc. 2011, 133, 13753–13760. PMCID: PMC3163434
  8. Peck, S.C.; Cooke, H.A.; Cicchillo, R.M.; Nair, S.K.; van der Donk W.A.* “Mechanism and Substrate Recognition of Hydroxyethylphosphonate Dioxygenase” Biochemistry 2011, 50, 6598-6605. PMCID: PMC3143709
  9. Borisova, S.A.; Christman, H.D.; Mourey-Metcalf, M.E.; Zulkepli, N.A.; Zhang, J.K.; van der Donk, W.A.; Metcalf, W.W.* “Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021” J. Biol. Chem. 2011, 286, 22283-22290. PMCID: PMC3121374
  10. Knerr, P.J.; Tzekou, A.; Ricklin, D.; Qu, H.; van der Donk, W.A.*; Lambris, J.D.* “Synthesis and Activity of Thioether-containing Analogues of the Complement Inhibitor Compstatin” ACS Chem. Biol. 2011, 6, 753-760. PMCID: PMC3137721
  11. Gut, I.M.; Blanke, S.R. *; van der Donk, W.A.* “Mechanism of Nisin Inhibition of Bacillus anthracis Spore Outgrowth” ACS Chem. Biol. 2011, 6, 744-752. PMCID: PMC3178273
  12. Circello, B.T.; Miller, C.G.; Lee, J.-H.; van der Donk,W.A.; Metcalf, W.W.* “The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella entericaAntimicrob. Agents Chemother. 2011, 55, 3357-3362. PMCID: PMC3122408
  13. Whitteck, J.T.; Malova, P.; Peck, S.C.; Cicchillo, R.M.; Hammerschmidt, F.*; van der Donk, W.A.* “On the Stereochemistry of 2-Hydroxyethylphosphonate Dioxygenase” J. Am. Chem. Soc. 2011, 133, 4236-4239. PMCID: PMC3069692
  14. Gut, I.M.; Tamilselvam, B.; Prouty, A.M.; Stojkovic, B.; Czeschin, S.; van der Donk, W.A.*; Blanke S.R.* “Bacillus anthracis spore interactions with mammalian cells: Relationship between germination state and the outcome of in vitro infections” BMC Microbiol. 2011, 11, 46. PMCID: PMC3060849
  15. Goto, Y.; Okesli, A.; van der Donk, W.A.* “Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL Lanthionine synthetase family” Biochemistry 2011, 50, 891-898. PMCID: PMC3031989
  16. Oman, T.J.; Boetcher, J.D.; Wang, H.; Okalibe, X.N.; van der Donk, W.A.* “Sublancin is not a Lantibiotic but an S-linked Glycopeptide” Nat. Chem. Biol. 2011, 2, 78-80. PMCID: PMC3060661
  17. Wu, G.; Lu, J.-M.; Kulmacz, R.J. van der Donk, W.A.; Tsai, A.L.* “Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects” J. Inorg. Biochem. 2011, 105, 382-390. PMCID: PMC3049311
  18. Lü, J.-M.; Rogge, C.E.; Wu, G.; Kulmacz, R.J. van der Donk, W.A.; Tsai, A.L.* “Cyclooxygenase reaction mechanism of PGHS — Evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping” J. Inorg. Biochem. 2011, 105, 356-365. PMCID: PMC3053578
  19. Tsai, A.L.*; Wu, G.; Rogge, C.E.; Lü, J.-M.; Peng, S.; van der Donk, W.A.; Palmer, G.; Gerfen, G.J.; Kulmacz, R.J. “Structural comparisons of arachidonic and acid-induced radicals formed by prostaglandin h synthase-1 and -2” J. Inorg. Biochem. 2011, 105 ,366-374. PMCID: PMC3073652
  20. Shi, Y.; Yang, X.; Garg, N.; van der Donk, W.A.* “Production of Lantipeptides in Escherichia coli
    Am. Chem. Soc. 2011, 133, 2338-2341.PMCID: PMC3044485
  21. Velásquez, J.E.; and van der Donk, W.A.* “Genome Mining for Ribosomally Synthesized Natural Curr. Opin. Chem. Biol. 2011 15 , 11-21. PMCID: PMC3090663
  22. Nair, S.K. and van der Donk, W.A.* “Structure and Mechanism of Enzymes Involved in Biosynthesis and Breakdown of the Phosphonates Fosfomycin, Dehydrophos, and Phosphinothricin” Arch. Biochem. Biophys. 2011 505, 13-21. PMCID: PMC3040005

2010


  1. Bindman, N.; Merkx R.; Koehler, R.; Herrman, N.; van der Donk, W.A.* “Photochemical Cleavage of Leader Peptides”
    Chem. Comm. 2010, 46, 8935-8937PMCID: PMC3100556
  2. van der Donk, W.A.; Krebs, C.; Bollinger Jr., J.M. “Substrate Activation by Iron Superoxo Intermediates” Curr. Opin. Struct. Biol. 2010, 20, 673-683. PMCID: PMC3030196
  3. Kuemin, M.; van der Donk, W.A.*Structure-activity relationships of the phosphonate antibiotic dehydrophos” Chem. Comm. 2010, 46, 7694-7696. PMCID: PMC3109733
  4. Lee, J.H; Bae, B.; Kuemin, M.; Circello, B.T. Metcalf, W.W.; Nair, S.K.; van der Donk W.A.*
    “Characterization and Structure of DhpI, a Phosphonate O-Methyltransferase Involved in      Dehydrophos Biosynthesis” Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 17557-17562.PMCID: PMC2955109
  5. Clark, K.M.; Yu, Y.; Marshall, N.; Sieracki, N.; Nilges, M.; Blackburn, N.; van der Donk, W.A.*; Lu, Y.* “Transforming a Blue Copper into a Red Copper Protein: Engineering Cysteine and Homocysteine into the Axial Position of Azurin using Site-Directed Mutagenesis and Expressed Protein Ligation” J. Am. Chem. Soc. 2010 132, 10093-10101. PMCID: PMC2929572
  6. Li, B.; Sher, D.; Kelly, L.; Shi, Y.; Huang, K.; Knerr, P.J.; Joewono, I.; Rusch, D.; Chisholm, S.W.*; van der Donk. W.A.*, “Catalytic Promiscuity in the Biosynthesis of Cyclic Peptide Secondary Metabolites in Planktonic Marine Cyanobacteria” Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 10430-10435. PMCID: PMC2890784
  7. Circello B.T.; Eliot A.C.; Lee, J.H.; van der Donk, W.A.; Metcalf, W.W.* “Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster” Chem. Biol. 2010, 17, 402-411. PMCID: PMC2888486
  8. Goto, Y.; Li, B.; Claesen, J.; Shi, Y.; Bibb, M.J.; van der Donk, W.A.* “Discovery of Unique Lantibiotic Synthetases Reveals Mechanistic and Evolutionary Insights” PLoS Biol. 2010, 8, e1000339. PMCID: PMC2843593
  9. Borisova, S.A.; Circello B.T.; van der Donk, W.A.*; Metcalf, W.W.* “Biosynthesis of Rhizocticins, Antifungal Phosphonate Oligopeptides Produced by Bacillus subtilis ATCC6633” Chem. Biol. 2010,1, 28-37. PMCID: PMC2819989
  10. Oman, T.; van der Donk, W.A.* “Follow the Leader: the Use of Leader Peptides to Guide Natural Product Biosynthesis” Nat. Chem. Biol.2010, 1, 9-18. PMCID: PMC3799897
  11. Cooper, L.E.; Li, B.; van der Donk, W.A.* “Biosynthesis and Mode of Action of Lantibiotics” in Comprehensive Natural Products II: Chemistry and Biology, Eds. Mander, L.; Liu, H.-W., Elsevier: Oxford, 2010. Volume 5, pp. 217-256.

2009


  1. Whitteck, J.T.; Cicchillo, R.M.; van der Donk, W.A.* “Hydroperoxylation by Hydroxyethyl-phosphonate Dioxygenase” J. Am. Chem. Soc. 2009, 131, 16225. PMCID: PMC2773148
  2. Wecksler, A.T.; Kenyon, V.; Garcia, N.K.; Deschamps, J.D.; van der Donk, W.A.; Holman, T.R.* “Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-Lipoxygenase-2” Biochemistry 2009, 36, 8721-8730. PMCID: PMC2746553
  3. Oman, T.; van der Donk, W.A.* “Insights into the Mode of Action of the Two-Component Lantibiotic Haloduracin” ACS Chem. Biol. 2009, 10, 865-74. PMCID: PMC2812937
  4. Levengood, M.R.; Knerr, P.J.; Oman, T.J.; van der Donk, W.A.* “In Vitro Mutasynthesis of Lantibiotic Analogs Containing Nonproteinogenic Amino Acids” J. Am. Chem. Soc. 2009, 131, 12024-25. PMCID: PMC2732204
  5. Lee, M.V.; Ihnken, L.A.F.; You, Y.O.; McClerren, A.L.; van der Donk, W.A.*; Kelleher, N.L.* “Distributive and Directional Behavior of Lantibiotic Synthetases Revealed by High-Resolution Tandem Mass Spectrometry” J. Am. Chem. Soc. 2009, 131, 12258-64. PMCID: PMC2735757
  6. Clark, K.M.; van der Donk, W.A.*; Lu, Y.* “Expressed Protein Ligation for Metalloprotein Design and Engineering”Methods Enzymol. 2009, 462, 98-115. PMCID: PMC2780537
  7. Zhang, X.; van der Donk, W.A.* “Using Expressed Protein Ligation to Probe the Substrate Specificity of Lantibiotic Synthetases” Methods Enzymol. 2009, 462, 117-134. PMCID: PMC2780537
  8. Lee, J.; Evans, B.S.; Li, G.; Kelleher, N.L.*; van der Donk, W.A.* “In vitro Characterization of a Heterologously Expressed Non-Ribosomal Peptide Synthetase Involved in Phosphinothricin Tripeptide Biosynthesis” Biochemistry 2009, 48, 5054-5056. PMCID: PMC2709985
  9. Wecksler, A.T.; Jacquot, C.; van der Donk, W.A.*; Holman, T.R.* “Mechanistic Investigations of Human Reticulocyte15- and Platelet 12-Lipoxygenases with Arachidonic Acid” Biochemistry 2009, 48, 6259-67. PMCID: PMC2935259
  10. Cicchillo, R.M.; Zhang, H.; Blodgett, J.A.V.; Whitteck, J.T.; Li, G.; Nair, S.K.*; van der Donk, W.A.*; Metcalf, W.W.* “An Unusual Carbon-Carbon Bond Cleavage Reaction During Phosphinothricin Biosynthesis” Nature 2009, 459, 871-874. PMCID: PMC2874955
  11. You, Y.O.; Levengood, M. R.; Furgerson Ihnken, L.A.; Knowlton, A.K., van der Donk, W.A.* “Lacticin 481 Synthetase as a General Ser/Thr Kinase” ACS Chem. Biol.2009, 4, 379-385. PMCID: PMC2709986
  12. Li, B.; Cooper, L.E.; van der Donk, W.A.* “In vitro Studies of Lantibiotic Biosynthesis” Methods Enzymol. 2009, 458, 533-558.
  13. Levengood, M.R.; Kerwood, C.C.; Chatterjee, C.; van der Donk, W.A.* “Investigation of the Substrate Specificity of Lacticin 481 Synthetase Using Nonproteinogenic Amino Acids” ChemBioChem 2009, 10, 911-919. PMCID: PMC2737179
  14. Metcalf, W.W.; van der Donk, W. A. “Biosynthesis of Phosphonic and Phosphinic Acid Natural Products”  Ann. Rev. Biochem. 2009, 78, 65-94. PMCID: PMC2729427
  15. Furgerson, L.A.; van der Donk, W.A* “Lantibiotics, Biosynthesis and Mode of Action of” in Wiley Encyclopedia of Chemical Biology, Begley, T.P., Ed. John Wiley & Sons, Inc., 2009.

2008


  1. Barry, A.N.; Clark, K.M.; Otoikhian, A.; van der Donk, W.A.; Blackburn, N.* “Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase” Biochemistry 2008, 47, 13074-13083. PMCID: PMC2645929
  2. Jacquot, C.; McGinley, C.M.; Plata, E.; van der Donk, W.A.* “Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases” Org. Biomol. Chem. 2008, 6, 4242-4252. PMCID: PMC2883171
  3. Gut, I.M.; Prouty, A.M.; Ballard, J. D.; van der Donk, W.A.*; Blanke, S.R.* “Inhibition of Bacillus anthracis Spore Outgrowth by Nisin” Antimicrob. Agents Chemother. 2008, 52, 4281-8428. PMCID: PMC2592879
  4. Cooper, L.E.; McClerren, A.L; Chary, A.; van der Donk, W.A.* “Structure-Activity Relationship Studies of the Two-Component Lantibiotic Haloduracin” Chem. Biol. 2008, 15, 1025-1045. PMCID: PMC2633096
  5. Jacquot, C.; Peng, S.; van der Donk, W.A.* “Kinetic Isotope Effects in the Oxidation of Arachidonic Acid by Soybean Lipoxygenase-1” Bioorg. Med. Chem. Lett. 2008, 18 5959-5962. PMCID: PMC2652760
  6. Furgerson Ihnken, L.A.; Chatterjee, C.; van der Donk, W.A.* “In Vitro Reconstitution and Substrate Specificity of a Lantibiotic Protease”Biochemistry 2008, 47 7352-7363. PMCID: PMC2574596
  7. Patton, G.C.; Paul, M.; Cooper, L.E.; Chatterjee, C.; van der Donk, W.A.* “The Importance of the Leader Sequence for Directing Lanthionine Formation in Lacticin 481”Biochemistry 2008, 47 7342-7351. PMCID: PMC2574844
  8. Jacquot, C.; Wecksler, A.T.; McGinley, C.M.; Segraves, E.N.; Holman, T.R.*; van der Donk, W.A.* “Isotope Sensitive Branching and Kinetic Isotope Effects in the Reaction of Deuterated Arachidonic Acids with Human 12- and 15-Lipoxygenases” Biochemistry 2008, 47, 7295-7303. PMCID: PMC2574664
  9. Shao, Z.; Blodgett, J.A.V.; Circello, B.T.; Eliot, A.C.; Woodyer, R.; Li, G.; van der Donk, W.A., Metcalf, W.W.; Zhao, H.* “Biosynthesis of 2-Hydroxyethylphosphonate, an Unexpected Intermediate Common to Multiple Phosphonate Biosynthetic Pathways” J. Biol. Chem. 2008, 283, 23161-23168. PMCID: PMC2516978
  10. Levengood, M.R.; van der Donk, W.A.* Use of Lantibiotic Synthetases for the Preparation of Bioactive Constrained Peptides” Bioorg. Med. Chem. Lett. 2008, 18, 3025-3028. PMCID: PMC2452991

2007


  1. Fogle, E.J.; van der Donk, W.A.* “Pre-Steady State Studies of Phosphite Dehydrogenase Demonstrate that Hydride Transfer is Fully Rate-Limiting” Biochemistry 2007, 46, 13101-13108. PMCID: PMC2517116
  2. Whitteck, J.T.; Ni, W.; Griffin, B.M.; Eliot, A.C.; Thomas, P.M.; Kelleher, N.M.; Metcalf, B.W.; van der Donk, W.A.* “Reassignment of the Structure of the Antibiotic A53868 Reveals an Unusual Amino Dehydrophosphonic Acid” Angew. Chem. Intl. Ed. Engl. 2007, 46, 9089-9092.
  3. van der Donk, W.A.*; Booker, S.J.* “Never Stop Questioning” Curr.Opin. Chem. Biol. 2007, 11, 527-528.
  4. Levengood, M.R.; Patton, G.C.; van der Donk, W.A.* “The Leader Peptide is not Required for Post-translational Modification by Lacticin 481 Synthetase” J. Am. Chem. Soc. 2007, 129, 10314-10315. PMCID: PMC2492579
  5. Zhang, X.; Ni, W.; van der Donk, W.A.* “On the Regioselectivity of Thioether Formation by Lacticin 481 Synthetase” Org. Lett. 2007, 9, 3343-3346. PMCID: PMC2517117
  6. Willey, J.M.*; van der Donk, W.A.* “Lantibiotics: Peptides of Diverse Structure and Function” Ann. Rev. Microbiol. 2007, 61, 477-501.
  7. Blodgett, J.A.V.; Thomas, P.M.; Li, G.; Velasquez, J.E.; van der Donk, W.A.; Kelleher, N.L.; Metcalf, W.W.* “Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide” Nat. Chem. Biol. 2007, 3, 480-485. PMCID: PMC4313788
  8. McGinley, C.M.; Jacquot, C.; van der Donk, W.A.* “Synthesis of 7-Thiaarachidonic Acid as a Mechanistic Probe of Prostaglandin H Synthase-2” Bioorg. Med. ChemLett.2007, 17, 4049-4052. PMCID: PMC2040112
  9. Li, B.; van der Donk, W.A.* “Identification of Essential catalytic Residues of the Nisin Cyclase NisC” J. Biol. Chem. 2007, 282, 21169-21175.
  10. Paul, M; Patton, G.C.; van der Donk, W.A.* “Mutants of the Zinc Ligands of Lacticin 481 Synthetase Retain Dehydration Activity but Have Impaired Cyclization Activity” Biochemistry 2007, 46, 6268-76. PMCID: PMC2517114
  11. You, Y.O.; van der Donk, W.A.* “Mechanistic Investigations of the Dehydration Reaction of Lacticin 481 Synthetase Using Site-Directed Mutagenesis” Biochemistry 2007, 46, 5991-6000.
    PMCID: PMC2517115
  12. Zhang, X.; van der Donk, W.A.* “On the Substrate Specificity of Dehydration by Lacticin 481 Synthetase” J. Am. Chem. Soc. 2007, 129, 2212-2213. PMCID: PMC2517113
  13. Li, G.; van der Donk, W.A.* “Efficient Synthesis of Suitably Protected β-Difluoroalanine and γ-Difluorothreonine from L-Ascorbic Acid” Org. Lett. 2007, 9, 41-44. PMCID: PMC2593874
  14. Levengood, M.; van der Donk, W.A.* “Dehydroalanine-containing peptides: preparation from phenylselenocysteine and utility in convergent ligation strategies” Nat. Protocols 2007, 1, 3001-3010.
  15. Woodyer, R.; Li, G.; Zhao, H.;* van der Donk, W.A.* “New Insight into the Mechanism of Methyl Transfer During the Biosynthesis of Fosfomycin” Chem. Comm. 2007, 359-361.

2006


  1. Woodyer, R. D.; Shao, Z.; Metcalf, W. M.; van der Donk, W. A.;* Zhao, H.* “Heterologous Production of Fosfomycin and Identification of the Minimal Biosynthetic Gene Cluster” Chem. Biol. 2006, 13, 1171-1182.
  2. van der Donk, W.A.* “Rings, Radicals, and Regeneration: the Early Years of a Bioorganic Laboratory” J. Org. Chem. 2006, 71, 9561-9571. PMCID: PMC2519235
  3. Chatterjee, C.; Patton, G. C.; Cooper, L.; Paul, M.; Xie, L.; Ni, W.; van der Donk, W. A.* “Engineering Dehydro Amino Acids and Thioethers into Peptides Using Lacticin 481 Synthetase” Chem & Biol. 2006, 13, 1109-1117.
  4. McClerren,A.L.; Cooper, L.E.; Quan, C.; Thomas, P.M.; Kelleher, N.L.; van der Donk, W.A.* “Discovery and in vitro Biosynthesis of Haloduracin, a New Two-component Lantibiotic” Proc. Natl. Acad. Sci. USA 2006, 103, 17243-17248.
  5. Relyea, H.A.; van der Donk, W.A.* “Nature’s Way to Make the Lantibiotics” J. Chem. Educ., 2006, 83, 1769.
  6. Liu, W.; Wang, L.H.; Pavol, F.; Hayashi, Y.; McGinley, C.M.; van der Donk, W.A.; Kulmacz, R.* “Arabidopsis thaliana Fatty Acid Alpha-dioxygenase-1: Evaluation of Substrates, Inhibitors, and Amino-Terminal Function” Plant Physiol. Biochem. 2006, 44, 284-293.
  7. van der Donk, W.A. “Lighting Up the Nascent Cell Wall” ACS Chem Biol. 2006, 1, 425–428.
  8. McGinley, C. M.; van der Donk, W. A.* “Synthesis of Site-Specifically Deuterated Arachidonic Acid Derivatives Containing a Remote Tritium Radiolabel” J. Label. Cmpd. Radiopharm.2006, 49, 545-558.
  9. Pesavento, R.P.; Pratt, D.A.; Jeffers, J.; van der Donk, W.A.* “Model Studies of the CuB Site of Cytochrome c Oxidase Utilizing a Zn(II) Complex Containing an Imidazole-Phenol Cross-Linked Ligand” Dalton Trans. 2006, 3326-3337.
  10. Li, B.; Yu, J.-P. J.; Brunzelle, J. S.; Moll, G. N.; van der Donk, W. A.;* Nair, S. K.* “Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin Biosynthesis” Science, 2006, 311, 1464.
  11. Miller, L. M.; Chatterjee, C.; van der Donk, W. A.; Kelleher, N. L.* “The Dehydratase Activity of Lacticin 481 Synthetase is Highly Processive” J. Am. Chem. Soc. 2006, 128, 1420-1421.PMCID: PMC2532561
  12. McGinley, C.M.; Relyea, H.A.; van der Donk, W.A.* “Vitamin B12 Catalyzed Radical Cyclizations of Arylalkenes” Synlett, 2006, 211-214.
  13. Pratt, D.A.; van der Donk, W.A.* “On the Role of Alkylcobalamins in the Vitamin B12-Catalyzed Reductive Dehalogenation of Perchloroethylene and Trichloroethylene” Chem. Commun.2006, 558-560.
  14. Woodyer, R.; van der Donk, W.A. ;* Zhao, H. * “Optimizing a Biocatalyst for Improved NAD(P)H Regeneration: Directed Evolution of Phosphite Dehydrogenase” Comb. Chem. High Throughput Screen. 2006, 9, 237-245.

2005


  1. van der Donk, W.A. “The Protein Modification Repertoire” Nature Chem. Biol. 2005, 1, 243.
  2. Chatterjee, C.; Miller, L. M.; Leung, Y. L.; Xie, L.; Yi, M.; Kelleher, N.L.; van der Donk, W.A.* “Lacticin 481 Synthetase Phosphorylates its Substrate during Lantibiotic Production” J. Am. Chem. Soc. 2005, 127, 15332-15333.
  3. Ide, N.D.; Galonić, D.P.; van der Donk, W.A.; Gin, D.Y.* “Conjugation of Selenols with Aziridine-2-Carboxylic Acid-Containing Peptides” Synlett 2005, 2011-2014.
  4. Patton, G.C.; van der Donk, W.A.* “New Developments in Lantibiotic Biosynthesis and Mode of Action” Curr. Opin.Microbiol. 2005, 8, 543-551.
  5. Zhang, X.; Ni, W.; van der Donk, W.A.* “Synthesis of Nonproteinogenic Amino Acids to Probe Lantibiotic Biosynthesis” J. Org. Chem. 2005, 70, 6685-6692. PMCID:PMC2525736
  6. Woodyer, R.; Zhao, H.;* van der Donk, W.A.* “Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration” FEBS J. 2005, 272, 3816-3827.
  7. Pratt, D.A.; Pesavento, R.P.; van der Donk, W.A.* “Model Studies of the Histidine-Tyrosine Cross-Link in Cytochrome c Oxidase Reveal the Flexible Substituent Effect of the Imidazole Moiety” Org. Lett. 2005, 7, 2735-2738.
  8. Galonić, D. P.; Ide, N. D.; van der Donk, W. A.;* Gin, D. Y. * “Aziridine-2-Carboxylic Acid-Containing Peptides: Application to Solution- and Solid-Phase Convergent Site-Selective Peptide Modification” J. Am. Chem. Soc. 2005, 127, 7359-69.
  9. Relyea, H.A.; Wheatley, J. L.; Woodyer, R.; Rimkus, S.; van der Donk, W.A.* “Inhibition and pH Dependence of Phosphite Dehydrogenase” Biochemistry 2005, 44, 6640-6649.
  10. Woodyer, R.; Wheatley, J. L.; Relyea, H.A.; Rimkus, S.; van der Donk, W.A.* “Site-Directed Mutagenesis of Active Site Residues of Phosphite Dehydrogenase” Biochemistry 2005, 44, 4765-4774.
  11. Relyea, H.A.; van der Donk, W.A.* “Mechanism and Applications of Phosphite Dehydrogenase” Bioorg. Chem. 2005, 33, 171-89.
  12. Woodyer, R.; Simurdiak, M.; van der Donk, W.A. ;* Zhao, H.* “Heterologous Expression, Purification, and Characterization of a Highly Active Xylose Reductase from Neurospora crassaAppl. Environ. Microbiol.2005, 71, 1642-1647. PMC ID: PMC1065158
  13. McCauley, K.M.; Pratt, D.A.; Wilson, S. R.; Shey, J.; Burkey, T.J.; van der Donk, W.A.* “Properties and Reactivity of Chlorovinylcobalamin and Vinylcobalamin and Their Implications for Vitamin B12-Catalyzed Reductive Dechlorination of Chlorinated Alkenes” J. Am. Chem. Soc. 2005, 127, 1126-1136.
  14. Chatterjee, C. Paul, M.; Xie, L.; van der Donk, W.A.* “Biosynthesis and Mode of Action of Lantibiotics” Chem. Rev.2005, 105, 633-684.
  15. Pratt, D. A.;* van der Donk, W.A.* “Theoretical Investigations into the Intermediacy of Chlorinated Vinyl Cobalamins in the Reductive Dehalogenation of Chlorinated Ethylenes” J. Am. Chem. Soc. 2005, 127, 384-396.
  16. Galonić, D.; van der Donk, W.A.;* Gin, D.Y.* “Site-Selective Conjugation of Thiols with Aziridine-2-Carboxylic Acid-Containing Peptides” J. Am. Chem. Soc.2004, 126, 12712-12713.
  17. Xie, L.; van der Donk, W.A.* “Post-Translational Modifications during Lantibiotic Biosynthesis” Curr. Opin. Chem. Biol.2004, 8, 498-507.
  18. Paul, M.; van der Donk, W.A.* “Chemical and Enzymatic Synthesis of Lanthionines” Minirev. Org. Chem.2005, 1, 23-37.

2004


  1. Ralle, M.; Berry, S. M.; Gieselman, M.D.; Nilges, M.J.; van der Donk, W.A.; Lu, Y.; Blackburn, N. J.* “The Selenocysteine Substituted Blue Copper Center: Spectroscopic Investigations of Cys112SeCys Pseudomonas aeruginosa Azurin”J. Am. Chem. Soc. 2004, 126, 7244-7256.
  2. Xie, L.; Miller, L.; Chatterjee, C.; Averin, O.; Kelleher, N.L.;* van der Donk, W.A.* “Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity” Science 2004, 303, 679-681.
  3. Peng, S.; McGinley, C.M.; .van der Donk, W.A.* “Synthesis of Site-Specifically Labeled Arachidonic Acids as Mechanistic Probes for Prostaglandin H Synthase” Org. Lett. 2004, 6, 349-352.

2003


  1. McGinley, C.M.; van der Donk, W.A.* “Enzymatic Hydrogen Atom Abstraction from Polyunsaturated Fatty Acids” Chem. Commun.2003, 2843-2846.
  2. Okeley, N.M.; Paul, M.; Stasser, J.P.; Blackburn, N.J.;* van der Donk, W.A.* “SpaC and NisC, the Cyclases Involved in Subtilin and Nisin Biosynthesis, Are Zinc Proteins” Biochemistry 2003, 42, 13613-13624.
  3. Galonić, D. P.; van der Donk, W.A.;* Gin, D.Y.* “Oligosaccharide-Peptide Ligation of Glycosyl Thiolates with Dehydropeptides: Synthesis of S-Linked Mucin-Related Glycopeptide Conjugates” Chem.–Eur. J. 2003, 24, 5997-6006.
  4. Zhao, H.;* van der Donk, W.A.* “Regeneration of Cofactors for Use in Biocatalysis” Curr. Opin. Biotechnol. 2003, 14, 583-589.
  5. Woodyer, R.; van der Donk, W. A.;* Zhao, H.* “Relaxing the Nicotinamide Cofactor Specificity of Phosphite Dehydrogenase by Rational Design” Biochemistry 2003, 42, 11604-11614.
  6. Zhu, Y.; Gieselman, M. D.; Zhou, H.; Averin, O.; van der Donk, W.A.*“Biomimetic studies on the mechanism of stereoselective lanthionine formation” Org. Biomol. Chem. 2003, 1, 3304-3315.
  7. Zhou, H.; Schmidt, D. M. Z.; Gerlt, J. A.;* van der Donk, W.A.* “Chemical and Enzymatic Synthesis of Fluorinated-Dehydroalanine-Containing Peptide” ChemBioChem, 2003, 4, 1206-1215.
  8. van der Donk, W.A**; Zhao, H.* “Recent Developments in Pyridine Nucleotide Regeneration” Curr. Opin. Biotechnol. 2003, 14, 421-426.
  9. Peng, S.; van der Donk, W.A.* “An Unusual Isotope Effect on Substrate Inhibition in the Oxidation of Arachidonic Acid by Lipoxygenase” J. Am. Chem. Soc. 2003, 125, 8988-8989.
  10. Kulmacz, R.J**; van der Donk, W.A.; Tsai, A.-L. “Comparison of the Properties of Prostaglandin H Synthase-1 and -2” Progr. Lipid Res. 2003, 42, 377-404.
  11. Blomberg, M. L.;* Blomberg, M.R.A.; Siegbahn, P. E. M.; van der Donk, W. A.; Tsai, A.-L. “A Quantum Chemical Study of the Synthesis of Prostaglandin G2 by the Cyclooxygenase Active Site in Prostaglandin Endoperoxide H Synthase 1” J. Phys. Chem. B, 2003, 107, 3297-3308.
  12. McCauley, K.M.; Wilson, S.S.R.; van der Donk, W.A* “Characterization of Chlorovinylcobalamin, A Putative Intermediate in Reductive Degradation of Chlorinated Ethylenes” J. Am. Chem. Soc. 2003, 125, 4410-4411.

2002


  1. van der Donk, W.A.;* Tsai, A.-L.; Kulmacz, R.J. “The Cyclooxygenase Reaction Mechanism” Biochemistry 2002, 41, 15451-15458.
  2. Hellwig, P.;* Pfitzner, U.; Behr, J.; Rost;, B. Pesavento, R.P.; van der Donk, W.A.; Gennis, R.B.;  Michel, H.; Ludwig, B.; Mantele, W. “Vibrational modes of tyrosines in cytochrome c oxidase from Paracoccus denitrificans: FTIR and electrochemical studies on Tyr-D4-labeled and on Tyr280His and Tyr35Phe mutant enzymes” Biochemistry 2002, 41, 9116-9125.
  3. McCauley, K.M.; Wilson, S.S.R.; van der Donk, W.A.* “Dichloroacetylene Is Not the Precursor to Dichlorinated Vinylcobaloxime and Vinylcobalamin in Cobalt Catalyzed Dechlorination of Perchloro- and Trichloroethylene” Inorg. Chem. 2002, 41, 5844-5848.
  4. Nonnenberg, C.; van der Donk, W.A.;* Zipse, Z.* “Reductive Dechlorination of Trichloroethylene: A Computational Study” J. Phys. Chem. A 2002, 106, 8708-8715.
  5. Peng, S.; Okeley, N.M.; Tsai, A.L.; Wu, G.; Kulmacz, R.J.; van der Donk, W.A.* “Synthesis of Isotopically Labeled Arachidonic Acids as Probes for the Reaction Mechanism of Prostaglandin H Synthase” J. Am. Chem. Soc. 2002, 124, 10785-10796.
  6. Xie, L.; Chatterjee, C.; Balsara, R.; Okeley, N.M.; van der Donk, W.A.* “Heterologous Expression and Purification of SpaB Involved in Subtilin Biosynthesis” Biochem.Biophys. Res. Commun. 2002, 295, 952-957.
  7. Vrtis, J.M.; White, A.K.; Metcalf, W.W.; van der Donk, W.A.* “Phosphite Dehydrogenase: A Versatile Cofactor-Regeneration Enzyme” Angew.Chemie Intl. Ed. Engl. 2002, 41, 3257-3259.
  8. Tsai, A. L.; Palmer, G.; Wu, G.; Peng, S.; Okeley, N. M.; van der Donk, W. A.; Kulmacz, R. J. “Structural Characterization of Arachidonyl Radicals Formed by Aspirin-treated Prostaglandin H Synthase-2” J. Biol. Chem. 2002, 277, 38311-38321.
  9. Gieselman, M.; Zhu, Y.; Zhou, H.; Galonic, D.; van der Donk, W.A.* “Selenocysteine Derivatives for Chemoselective Ligations” ChemBioChem 2002, 3, 709-716.
  10. Zhou, H.; van der Donk, W.A.* “Biomimetic Stereoselective Formation of Methyllanthionine” Org. Lett. 2002, 4, 1335-1338.
  11. Berry, S.; Gieselman, M.D.; Nilges, M.J.; van der Donk, W.A.;* Lu, Y.* “An Engineered Azurin Variant Containing a Selenocysteine Copper Ligand” J. Am. Chem. Soc. 2002, 124, 2084-2085.
  12. Shey, J.; McCauley, K.M.; Dearth, A.; Young, B.; van der Donk, W.A.* “Mechanistic Investigation of a Novel Vitamin B12-Catalyzed Carbon−Carbon Bond Forming Reaction, the Reductive Dimerization of Arylalkenes” J. Org. Chem. 2002, 67, 837-846.
  13. McCauley, K.M.; Wilson, S.R.; van der Donk, W.A.* “Synthesis and Characterization of Chlorinated Alkenylcobaloximes to Probe the Mechanism of Vitamin B12-Catalyzed Dechlorination of Priority Pollutants” Inorg. Chem. 2002, 41, 393-404.

2001


  1. Xie, L.; van der Donk, W.A.* “Homemade cofactors: Self-processing in galactose oxidase” Proc. Natl. Acad. Sci. USA 2001, 98, 12863-12865. PMC ID: PMC60785
  2. Pesavento, R.; van der Donk, W.A.* “Tyrosyl Radical Cofactors” Adv. Prot. Chem. 2001, 58, 317-385.
  3. Gieselman, M.; Xie, L.; van der Donk, W.A.* “Synthesis of a Selenocysteine-Containing Peptide by Native Chemical Ligation” Org. Lett. 2001, 3, 1331-1334.
  4. Zhu, Y.; van der Donk, W.A.* “Convergent Synthesis of Peptide Conjugates using Dehydroalanines for Chemoselective Ligations” Org. Lett. 2001, 3, 1189-1192.
  5. Peng, S.; Okeley, N.M.; Tsai, A.-L.; Wu, G.; Kulmacz, R.; van der Donk, W.A.* “Structural Characterization of a Pentadienyl Radical Intermediate Formed during Catalysis by Prostaglandin H Synthase-2” J. Am. Chem. Soc. 2001, 123, 3609-3610.
  6. Vrtis, J.M.; White, A.; Metcalf, W.W.; van der Donk, W.A.* “Phosphite Dehydrogenase: An unusual Phosphoryl Transfer Reaction” J. Am. Chem. Soc. 2001, 123, 2672-2673.
  7. Zhou, H.; van der Donk, W.A.* “Synthesis of 2-Amino-3-fluoroacrylic Acid Containing Peptides” Org. Lett. 2001, 3, 593-596.

2000


  1. Shey, J.; van der Donk, W.A.* “Mechanistic Studies on Vitamin B12-Catalyzed Dechlorination of Chlorinated Alkenes” J. Am. Chem. Soc. 2000, 122, 12403-12404.
  2. Okeley, N.M.; Zhu, Y.; van der Donk, W.A.* “Facile Chemoselective Synthesis of Dehydroalanine-Containing Peptides” Org. Lett. 2000, 2, 3603-3606.
  3. Okeley, N.M.; van der Donk, W.A.* “Novel Cofactors via Post-translational Modifications of Enzyme Active Sites” Chem. Biol. 2000, 7, R159-R171.
  4. McCauley, K.M.; Vrtis, J.M.; Dupont, J.; van der Donk, W.A.* “Insights into the Functional Role of the Tyrosine-Histidine Linkage in Cytochrome c Oxidase” J. Am. Chem. Soc. 2000, 122, 2403-2404.

Postdoctoral Research (Massachusetts Institute of Technology)

  1. van der Donk, W.A.; Yu, G.; Perez, L.; Sanchez, R.; Stubbe, J.; Samano, V.; Robins, M.J. “Detection of a New Substrate-Derived Radical during Inactivation of Ribonucleotide Reductase from Escherichia coli by Gemcitabine 5′-Diphosphate” Biochemistry 1998, 6419-6426.
  2. van der Donk, W.A.; Gerfen, G.J.; Griffin, R.G.; Stubbe, J. “Direct EPR Spectroscopic Evidence for an Allylic Radical Generated from (E)-2′-Fluoromethylene-2′-deoxycytidine 5′-Diphosphate by E. coli Ribonucleotide Reductase” J. Am. Chem. Soc. 1998, 120, 4252-4253.
  3. Stubbe, J.; van der Donk, W.A. “Protein Radicals in Catalysis” Chem. Rev. 1998, 98, 705-762.
  4. Gerfen, G.J.; van der Donk, W.A.; Yu, G.; Farrar, C.; Griffin, R.G.; Stubbe, J.; McCarthy, J.R.; Matthews, D.P.; Jarvi, E.T. “Characterization of a Substrate Derived Radical Detected During the Inactivation of Ribonucleotide Reductase from Escherichia coli by 2′-Fluoromethylene-2′-deoxycytidine 5′-Diphosphate” J. Am. Chem. Soc. 1998, 120, 3823-3835.
  5. van der Donk, W.A.; Zeng, C.; Biemann, K.; Stubbe, J.; Hanlon, A.; Kyte, J. “Identification of an Active Site Residue of the R1 Subunit of Ribonucleotide Reductase from E. coli: Characterization of Substrate Induced Polypeptide Cleavage by C225SR1” Biochemistry 1996, 35, 10058-10067.
  6. van der Donk, W.A.; Yu, G.; Silva, D.J.; Stubbe, J.; McCarthy, J.R.; Matthews, D.P.; Jarvi, E.T.; Resvick, R.J.; Wagner, E. “Inactivation of Ribonucleotide Reductase by (E)-2′-Fluoromethylene-2′-deoxycytidine 5′-diphosphate: A Paradigm for Nucleotide Mechanism Based Inhibitors” Biochemistry 1996, 35, 8381-8391.
  7. McCarthy, J.; Sunkara, P.; Matthews, D.; Bitonti, A.; Jarvi, E.; Sabol, J.; Resvick, R.; Huber, E.; van der Donk, W.; Yu, G.; Stubbe, J. “Design of a Fluoro Olefin Cytidine Nucleoside as a Bioprecursor of a Mechanism-Based Inhibitor of Ribonucleotide Reductase” ACS Symp. Ser.1996, 639, 246-264.
  8. van der Donk, W.A.; Stubbe, J.; Gerfen, G.J.; Bellew, B.F.; Griffin, R.G. “EPR Investigation of the Inactivation of E. coli Ribonucleotide Reductase with 2′-Azido-2′-deoxyuridine 5′-Diphosphate: Evidence for the Involvement of the Thiyl Radical of C225-R1” J. Am. Chem. Soc. 1995, 117, 8908-8916.
  9. Stubbe, J.; van der Donk, W.A. “Ribonucleotide Reductases: Radical Enzymes with Suicidal Tendencies” Chem. Biol. 1995, 2, 783-801.

Graduate Research (Rice University/Texas A&M University)

  1. Porte, A.; van der Donk, W.A. Burgess, K. “New and Efficient Synthesis of an Amino Acid for Preparing Phosphine-Functionalized Peptidomimetics” J. Org. Chem. 1998, 63, 5262-5264.
  2. Burgess, K.; van der Donk, W.A. “Asymmetric Hydroboration” in Advanced Asymmetric Synthesis, Stephenson, G.R., Ed.; Chapman & Hall, London, 1996, 181-211.
  3. Burgess, K.; van der Donk, W.A. “Tris(triphenylphosphine)rhodium(I) chloride” in Encyclopedia of Reagents for Organic Synthesis, Paquette, L., Ed.; Wiley, New York, 1995, 1253-1261.
  4. Burgess, K.; van der Donk, W.A. “Transition-metal Catalyzed Reactions of Boron Hydrides” in Encyclopedia of Inorganic Chemistry; Vol. 3, King, R.B., Ed.; Wiley, New York, 1994, 1420.
  5. Burgess, K.; van der Donk, W.A. “Titanium-Mediated Additions of Borohydride to Alkenes” J. Am. Chem. Soc. 1994, 116, 6561-6569.
  6. Burgess, K.; van der Donk, W.A. “The Importance of Phosphine-to-Rhodium Ratios in EnantioselectiveHydroborations” Inorg.Chim.Acta 1994, 220, 93-98.
  7. Burgess, K.; van der Donk, W.A. “On Titanium Catalyzed Additions of Borohydride to Alkenes”Organometallics 1994, 13, 3616-3620.
  8. Burgess, K.; van der Donk, W.A. “On Hydroborations of Alkenes catalyzed by Titanium Complexes”Tetrahedron Lett. 1993, 6817-6820.
  9. Burgess, K.; van der Donk, W.A.; Westcott, S.A.; Marder, T.B.; Baker, R.T.; Calabrese, J.C. “Reactions of Catecholborane with Wilkinson’s Catalyst: Implications for the Transition Metal-Catalyzed Hydroboration of Alkenes” J. Am. Chem. Soc. 1992, 114, 9350-9359.
  10. Burgess, K.; van der Donk, W.A.; Jarstfer, M.B.; Ohlmeyer, M.J. “Further Evidence for the Role of dp-pp Bonding in Rhodium-Mediated Hydroborations” J. Am. Chem. Soc. 1991, 113, 6139-6144.
  11. Burgess, K.; van der Donk, W.A.; Kook, A.M. “On Deuterium-Labeling Studies for Probing Rhodium-Catalyzed Hydroboration Reactions” J. Org. Chem. 1991, 56, 2949-2951.
  12. Burgess, K.; van der Donk, W.A.; Ohlmeyer, M.J. “Enantioselectivehydroborations Catalyzed by Rhodium(+1)-complexes” Tetrahedron Asymmetry 1991, 2, 613-621.

Undergraduate Research (Leiden University, the Netherlands)

  1. Haanstra, W.G.; van der Donk, W.A.J.W.; Driessen, W.L.; Reedijk, J.; Wood, J.S.; Drew, M.G.B. “Unusual Behaviour of the Thioether Function of the Ligand 1,8-Bis(3,5-dimethyl-1-pyrazolyl)-3,6-dithiaoctane (bddo) towards Transition-metal Salts. X-ray Structures of a Green and a Red Modification of [Cu(bddo)Cl2]” J. Chem. Soc. Dalton Trans. 1990, 10, 3123-3128.
  2. Haanstra, W.G.; van der Donk, W.A.J.W.; Driessen, W.L.; Reedijk, J.; Wood, J.S.; Drew, M.G.B. “Coordination Behaviour of the Ligand 1,9-Bis(3,5-dimethyl-1-pyrazolyl)-3,7-dithianonane (bddn) towards First Row Transition Metals. X-ray Structure of [Cu(bddn)(H2O)](BF4)2” Inorg.Chim.Acta 1990, 176, 299-305.

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