Publications by Date

PUBLICATIONS CHRONOLOGICAL
Independent Investigator (University of Illinois at Urbana-Champaign)
Check here on PubMed for most updated publication list.
*corresponding author

2017 | 2016| 2015 |2014 | 2013 | 2012| 2011| 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001| 2000

2017


254. Mahanta N, Zhang Z, Hudson GA, van der Donk WA, Mitchell DA.“Reconstitution and substrate specificity of the radical SAM thiazole C-methyltransferase in thiomuracin biosynthesis.” J Am Chem Soc. doi: 10.1021/jacs.7b00693.
253. Hetrick KJ, van der Donk WA.“Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era.” Curr Opin Chem Biol. 38:36-44.
252. Repka LM, Chekan JR, Nair SK, van der Donk WA.“Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.” Chem Rev. 2017 Jan 30. doi: 10.1021/acs.chemrev.6b00591.
251. He C, Zeng M, Dutta D, Koh TH, Chen J, van der Donk WA.“LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.” Sci Rep. 2017 Jan 20;7:40980. doi: 10.1038/srep40980.
250. Peck SC, Wang C, Dassama LM, Zhang B, Guo Y, Rajakovich LJ, Bollinger JM Jr, Krebs C, van der Donk WA.“O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase.” J Am Chem Soc. 2017 Jan 16. doi: 10.1021/jacs.6b12147.

2016


252. Huang Z, Wang KA, van der Donk WA.“New Insights into the Biosynthesis of Fosfazinomycin.” Chem Sci. 2016;7(8):5219-5223.
251. Peck SC, van der Donk WA.“Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes.” J Biol Inorg Chem. 2016 Oct 25.
250. Ortega MA, Cogan DP, Mukherjee S, Garg N, Li B, Thibodeaux GN, Maffioli S, Donadio S, Sosio M, Escano J, Smith L, Nair SK, van der Donk WA.“Two flavoenzymes catalyze the post-translational generation of 5-chlorotryptophan and 2-aminovinyl-cysteine during NAI-107 biosynthesis.” ACS Chem Biol. 2016 Dec 29. doi: 10.1021/acschembio.6b01031.
249. Olivares P, Ulrich EC, Chekan JR, van der Donk WA, Nair SK.“Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.” ACS Chem Biol. 2016 Dec 27. doi: 10.1021/acschembio.6b00939.
248. Mukherjee S, Huo L, Thibodeaux GN, van der Donk WA.“Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin” Org Lett. 2016, 18, 6188-6191.
247. Peck, S.C.; van der Donk, W.A.* “Go It Alone: Four Electron Oxidations by Mononuclear Non‐heme Iron Enzymes” J. Biol. Inorg. Chem., 2016, Epub ahead of print.
246. Zhang, Z.; Hudson, G.A.; Mahanta, N.; Tietz, J.I.; van der Donk, W.A.*; Mitchell, D.A.* “Biosynthetic timing and substrate specificity for the thiopeptide thiomuracin” J. Am. Chem. Soc. 2016, 138, 15511-15514.
245. Ulrich EC, van der Donk WA.“Cameo appearances of aminoacyl-tRNA in natural product biosynthesis.” Curr Opin Chem Biol. PMID: 27599269.
244. Tang, W; Thibodeaux, GN; van der Donk, W.A.*“The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis.” ACS Chem. Biol. PMID: 27348535.
243. Thibodeaux, C.J.; Wagoner, J.; Yu, Y.; van der Donk, W.A.* “The Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis” J. Am. Chem. Soc. 2016. PMID: 27123925.
242. Huo, L.; van der Donk, W.A.* “Discovery and characterization of bicereucin, an unusual D-amino acid-containing mixed two-component lantibiotic”J. Am. Chem. Soc. 2016, 138, 16, 5254-7.
241. Huang, Z.; Wang, K.-K.A.; van der Donk, W.A.* “New Insights into the Biosynthesis of Fosfazinomycin” Chem. Sci., 2016.
240. Garg, N.; Goto, Y.; van der Donk, W.A.* “Characterization of the stereochemical configuration of lanthionine formation by the lanthipeptide synthetase GeoM” Biopolymers, PMID: 27178086.
239. Ortega, M. A.; van der Donk, W.A.* “Deciphering the Biosynthetic Logic of Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products” Cell Chem. Biol. 2016, 23, 1, 31-44.
238. Ding, W.; Liu, W.-Q.; Jia, Y.; Li, Y.; van der Donk, W.A.*; Zhang, Q.* “Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes” Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 13.
237. Ortega, M.A.; Hao, Y.; Walker, M.C.; Donadio, S.; Sosio, M.; Nair, S.K.;* van der Donk, W.A.* “Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis” Cell Chem. Biol. 2016, 23, 3, 370-380.
236. Zhao, X.; van der Donk, W.A.* “Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium” Cell Chem. Biol. 2016, 23, 246-256.

2015


235. Hudson, G.; Zhang, Z.; Tietz, J.; Mitchell, D.A.*; van der Donk, W.A.* “In vitro biosynthesis of the core scaffold of the thiopeptide thiomuracin” J. Am. Chem. Soc. 2015, 137, 16012-16015.
234. Yang, X.: van der Donk, W.A.* “Posttranslational introduction of D-alanine into ribosomally synthesized peptides by the dehydroalanine reductase NpnJ” J. Am. Chem. Soc. 2015, 137, 12426-12429.
233. Tang, W.; Dong, S.-H.; Repka, L.M.; He, C.; Nair, S.K.*; van der Donk, W.A.* “Applications of the Class II Lanthipeptide Protease LicP for Sequence-Specific, Traceless Peptide Bond Cleavage” Chem. Sci. 2015, 6, 6270-6279.
232. Garcia De Gonzalo, C.V.; Denham, E.L.; Mars, R.A.T.; Stülke, J.; van der Donk, W.A.*; van Dijl, J.M.* “The Phosphoenolpyruvate:Sugar Phosphotransferase system is involved in sensitivity to the glucosylated bacteriocin sublancin” Antimicrob. Agents Chemother. 2015, 59, 6844-6854.
231. Medema, M.H.*; Kottmann, R.; Yilmaz, P.; Cummings, M.; Biggins, J.B.; Blin, K.; de Bruijn, I.; Chooi. Y.H.; Claesen, J.; Coates, R.C.; Cruz-Morales, P.; Duddela, S.; Düsterhus, S.; Edwards, D.J.; Fewer, D.P.; Garg, N.; Geiger, C.; Gomez-Escribano, J.P.; Greule, A.; Hadjithomas, M.; Haines, A.S.; Helfrich, E.J.; Hillwig, M.L.; Ishida, K.; Jones, A.C.; Jones, C.S.; Jungmann, K.; Kegler, C.; Kim, H.U.; Kötter, P.; Krug, D.; Masschelein, J.; Melnik, A.V.; Mantovani, S.M.; Monroe, E.A.; Moore, M.; Moss, N.; Nützmann, H.W.; Pan, G.; Pati, A.; Petras, D; Reen, F.J.; Rosconi, F.; Rui, Z.; Tian, Z.; Tobias, N.J.; Tsunematsu, Y.; Wiemann, P.; Wyckoff, E.; Yan, X.; Yim, G.; Yu, F.; Xie, Y.; Aigle, B.; Apel, A.K.; Balibar, C.J.; Balskus, E.P.; Barona-Gómez, F.; Bechthold, A.; Bode, H.B.; Borriss, R.; Brady, S.F.; Brakhage, A.A.; Caffrey, P.; Cheng, Y.Q.; Clardy, J.; Cox, R.J.; De Mot, R.; Donadio, S.; Donia, M.S.; van der Donk, W.A.; Dorrestein, P.C.; Doyle, S.; Driessen, A.J.; Ehling-Schulz, M.; Entian, K.D.; Fischbach, M.A.; Gerwick, L.; Gerwick, W.H.; Gross, H.; Gust, B.; Hertweck, C.; Höfte, M.; Jensen, S.E.; Ju, J.; Katz, L.; Kaysser, L.; Klassen, J.L.; Keller, N.P.; Kormanec, J.; Kuipers, O.P.; Kuzuyama, T.; Kyrpides, N.C.; Kwon, H.J.; Lautru, S.; Lavigne, R.; Lee, C.Y.; Linquan, B.; Liu, X.; Liu, W.; Luzhetskyy,  A.; Mahmud, T.; Mast, Y.; Méndez, C.; Metsä-Ketelä, M.; Micklefield, J.; Mitchell, D.A.; Moore,  B.S.; Moreira, L.M.; Müller, R.; Neilan, B.A.; Nett, M.; Nielsen, J.; O’Gara, F.; Oikawa, H.; Osbourn, A.; Osburne, M.S.; Ostash, B.; Payne, S.M.; Pernodet, J.L.; Petricek, M.; Piel, J.; Ploux,  O.; Raaijmakers, J.M.; Salas, J.A.; Schmitt, E.K.; Scott, B.; Seipke, R.F.; Shen, B.; Sherman, D.H.; Sivonen, K.; Smanski, M.J.; Sosio, M.; Stegmann, E.; Süssmuth, R.D.; Tahlan, K.; Thomas, C.M.; Tang, Y.; Truman, A.W.; Viaud, M.; Walton, J.D.; Walsh, C.T.; Weber, T.; van Wezel, G.P.; Wilkinson, B.; Willey, J.M.; Wohlleben, W.; Wright, G.D.; Ziemert, N.; Zhang, C.; Zotchev, S.B.;  Breitling, R.; Takano, E.; Glöckner, F.O. “Minimum Information about a Biosynthetic Gene cluster” Nat. Chem. Biol. 2015, 11, 625-631. 230. Walker, M.; van der Donk, W.A.* “The Many Roles of Glutamate in Metabolism” J. Ind. Microbiol. Biotechnol. 2015, 43, 419-430.
229. Zhu, H.; Peck, S.C.; Bonnot, F.; van der Donk, W.A.; Klinman, J.P.* “Oxygen-18 Kinetic Isotope Effects of Non-heme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species” J. Am. Chem. Soc. 2015, 137, 10448-10451.
228. Huang, Z.; van der Donk, W.A.* “An Unexpected Role for Ergothioneine” National Science Review 2015, 2, 382-383.
227. Dong, S.-H.; Tang, W.; Lukk, T.; Nair, S.K.*; van der Donk, W.A.* “The Enterococcal Cytolysin Synthetase Has an Unanticipated Lipid Kinase Fold” eLIFE, 2015, 4:e07607. PMCID: PMC4550811
226. Ju, K.-S.; Gao, J.; Doroghazi, J.R.; Lia, S.; Metzger, E.; Fudala, J.; Su, J.; Zhang, J.; Cioni, J.P.; J. Lee; Evans, B.S.; Hirota, R.; Labeda, D.P.; van der Donk, W.A.*; Metcalf, W.W.* “Discovery of Phosphonic Acid Natural Products by Genome Mining of 10,000 Actinomycetes” Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 12175-12180.
225. Bindman, N.A.; Bobeica, S.; Liu, W.R*; van der Donk, W.A.* “Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid” J. Am. Chem. Soc. 2015, 137, 6975-6978. PMCID: PMC4505723
224. van der Donk, W.A. “Bacteria Do It Differently: An Alternative Path to Squalene” ACS Central Sci. 2015, 1, 64-65.
223. Zhang, Q.; Doroghazi, J.R.; Zhao, X.; Walker, M.C.; van der Donk, W.A.* “Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in Actinobacteria”
Appl. Environ. Microbiol. 2015, 81, 4339-4350. PMCID: PMC4475899
222. Yu, Y.; Mukherjee, S.; van der Donk, W.A.* “Product Formation by the Promiscuous Lanthipeptide Synthetase ProcM is under Kinetic Control” J. Am. Chem. Soc. 2015, 137, 5140-5148. PMCID: PMC4487812
221. Yang, X.; van der Donk, W.A.* “The Michael-type cyclizations in lantibiotic biosynthesis are reversible” ACS Chem. Biol. 2015, 10, 1234-1238. PMCID: PMC4433588
220. Peck, S.C.; Chekan, J.R.; Ulrich E.C.; Nair, S.K.; van der Donk, W.A.* “A Common Late-Stage Intermediate in Catalysis by 2-Hydroxyethyl-phosphonate Dioxygenase and Methylphosphonate Synthase” J. Am. Chem. Soc. 2015, 137, 3217-3220. PMCID: PMC4487810
219. Thibodeaux, G.N.; McClerren, A.L.; Ma, Y.; Gancayco, M.R.; van der Donk, W.A.* “Synergistic binding of the leader and core peptide by the lantibiotic synthetase HalM2” ACS Chem. Biol. 2015, 10, 970-977. PMCID: PMC4414810
218. Huang, Z.; Wang, K.-K.A.; Lee, J.; van der Donk, W.A.* “Biosynthesis of fosfazinomycin is a convergent process” Chem. Sci. 2015, 6, 1282-1287. PMCID: PMC4303578
217. Tang, W.; Jimenez-Oses, G.; Houk, K.N.*; van der Donk, W.A.* “Substrate Control in Stereoselective Lanthionine Biosynthesis” Nat. Chem. 2015, 7, 57-64. PMCID: PMC4270103
216. Ortega, M.A.; Hao, Y.; Zhang, Q.; Walker, M.C.; van der Donk, W.A.*, Nair, S.K.* “Structure and Mechanism of the tRNA-Dependent Lantibiotic Dehydratase NisB” Nature, 2015, 517, 509-512. PMCID: PMC4430201

2014


215. Thibodeaux, C.; Ha, T.; van der Donk, W.A.* “A Price to Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases, ProcM and HalM2” J. Am. Chem. Soc., 2014, 136, 17513-17529. PMCID: PMC4277782
214. Zeng, M.; van der Donk, W.A.*; Chen, J.* “Lantibiotic Cyclase-like protein 2 (LanCL2) is a novel regulator of Akt” Mol. Biol. Cell, 2014, 25, 3954-3961. PMCID: PMC4244203
213. van der Donk, W.A.*; Nair, S.K.* “Structure and Mechanism of Lanthipeptide Biosynthetic Enzymes” Curr. Opin. Struct. Biol. 2014, 29, 58-66. PMCID: PMC4267917
212. Zhang, Q.; Yang, X.; Wang, H.; van der Donk, W.A.* “High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis” ACS Chem. Biol. 2014, 2686-2694. PMCID: PMC4245175
211. Huang, Y.; Reis, E.S.; Knerr, P.J.; van der Donk, W.A.; Ricklin, D.; Lambris, J.D. “Conjugation to Albumin-Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin” ChemMedChem 2014, 9, 2223-2226. PMCID: PMC4177305
210. Zhang, Q.; Ortega, M.A.; Shi, Y.; Wang, H.; Melby, J.O.; Tang, W.; Mitchell, D.A.; van der Donk, W.A.* “Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS” Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 12031-12036. PMCID:PMC4143002
209. Mukherjee, S.; van der Donk, W.A.* “Mechanistic Studies on the Substrate Tolerant Lanthipeptide Synthetase ProcM” J. Am. Chem. Soc. 2014, 136, 10450-10459. PMCID: PMC4111213
208. Ortega, M.A.; Velásquez, J.E.; Garg, N.; Zhang, Q.; Joyce, R.E.; Nair, S.K.*; van der Donk, W.A.* “Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO” Chem. Biol., 2014, 9, 1718–1725. PMCID: PMC4136673
207. Bindman, N. A; van der Donk, W.A.* RiPPs: Ribosomally Synthesized and Posttranslationally Modified Peptides. In Natural Products: Discourse, Diversity, and Design; Osbourn, A., Goss, R., Carter, G.T., Eds.; John Wiley & Sons, Inc.: Hoboken, NJ, USA, 2014; pp 197-217.
206. Ranaghan, K.E.; Hung, J.E.; Bartlett, G.J.; Mooibroek, T.J.; Harvey, J.N.; Woolfson, D.N.; van der Donk, W.A.*; Mulholland, A.J.* “A catalytic role for methionine revealed by a combination of computation and experiments on phosphite dehydrogenase” Chem. Sci. 2014, 5, 2191-2199.
205. Clark, K.M.; Yu, Y.; van der Donk, W.A.*; Blackburn, N.J.; Lu, Y.* “Modulating the Copper-Sulfur Interaction in Type 1 Blue Copper Azurin by Replacing Cys112 with Nonproteinogenic Homocysteine” Inorg. Chem. Front., 2014, 1, 153-158. PMCID: PMC3972132
204. Garcia De Gonzalo, C.V.; Zhu, L; Oman, T.J.; van der Donk, W.A.* “NMR structure of the S-linked glycopeptide sublancin 168” ACS Chem. Biol. 2014, 9, 796–801. PMCID: PMC3985867
203. Hung, J.; Fogle, E.J.; Garg, N.; Chekan, J.R.; Nair, S.K.; van der Donk, W.A.* “Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase” PLoS One 2014, 9, e87134. PMCID: PMC3909101
202. Wang, H.; Oman, T.J.; Zhang, R.; Garcia De Gonzalo, C.V.; Zhang, Q.; van der Donk, W.A.* “The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation” J. Am. Chem. Soc. 2014, 136, 84-87. PMCID: PMC3913795
201. Gao, J.; Ju, K.S.; Yu, X.; Velásquez, J.E.; Mukherjee, S.; Lee, J.; Zhao, C.; Evans, B.S.; Doroghazi, J.R.; Metcalf, W.W.*; van der Donk, W.A.* “Use of a Phosphonate Methyltransferase in the Identification of the Fosfazinomycin Biosynthetic Gene Cluster” Angew. Chem. Intl. Ed. 2014, 53, 1334-1337. PMCID: PMC3927463.
200. Agarwal, V.A.; Peck, S.C.; Chen, J-H.; Borisova, S.A.; Chekan, J.R.; van der Donk, W.A.*; Nair, S.K.* “Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate biodegradation” Chem. Biol. 2014, 21, 125-135. PMCID: PMC4313731
199. Garg, N.; Oman, T.J.; Wang, T.-S. A.; Garcia De Gonzalo, C.V.; Walker, S.; van der Donk, W.A.* “Mode of Action and Structure-Activity Relationship Studies of Geobacillin I” J. Antibiot. 2014 (67) 133-136. special issue in honor of Christopher T. Walsh. PMCID: PMC4004768

2013


198. Yu, Y.; Zhang, Q.; van der Donk, W.A.* “Insights into the Evolution of Lanthipeptide Biosynthesis” Protein Sci. 2013, 22, 1478-1489. Invited review for receiving the Kaiser award. PMCID: PMC3831664
197. Peck, S.P; van der Donk, W.A.* “Phosphonate Biosynthesis and Catabolism: A Treasure Trove of Unusual Enzymology” Curr. Opin. Chem. Biol. 2013, 17, 580-588. PMCID: PMC3764496
196. Bindman, N. A; van der Donk, W.A.* “A General Method for Site-Specific Fluorescent Labeling of Lanthipeptides and Its Application to Visualize their Cellular Localization” J. Am. Chem. Soc. 2013, 135, 10362–10371. PMCID: PMC3775354
195. Bougioukou, D.J.; Mukherjee, S.; van der Donk, W.A.* “Revisiting the Biosynthesis of Dehydrophos Reveals a tRNA Dependent Pathway” Proc. Natl. Acad. Sci. USA 2013, 110, 10952-10957. PMCID: PMC3704017
194. Knerr, P.J.; van der Donk, W.A.* “Chemical Synthesis of the Lantibiotic Lacticin 481 Reveals the Importance of Lanthionine Stereochemistry” J. Am. Chem. Soc. 2013, 135, 7094-7097. PMCID: PMC3736828
193. Peck, S.C.; van der Donk, W.A.* “Biochemistry: Positive and Radical” Nature 2013, 496, 34-35. Commentary.
192. Evans, B.S.*; Zhao, C.; Gao, J.; Evans, C.M.; Ju, K.S.; Doroghazi, J.R.; van der Donk, W.A.; Kelleher, N.L.; Metcalf, W.W. “Discovery of the Antibiotic Phosacetamycin via a New Mass Spectrometry-Based Method for Phosphonic Acid Detection” ACS Chem. Biol. 2013, 8, 908-913.
191. Garg, N.; Salazar-Ocampo, L.M.A.; van der Donk, W.A.* “In vitro activity of the Nisin Dehydratase NisB” Proc. Natl. Acad. Sci. USA 2013, 110, 7258-7263. PMCID: PMC3645518.
190. Yang, X.; van der Donk, W.A.* “Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products: New Insights Into the Role of Leader and Core Peptides During Biosynthesis” Chem. Eur. J. 2013, 24, 7662-7677. PMCID: PMC3838977
189. Tang, W.; van der Donk, W.A.* “The Sequence of the Enterococcal Cytolysin Imparts Unusual Lanthionine Stereochemistry” Nat. Chem. Biol. 2013, 9, 157-159. PMCID: PMC3578037

2012


188. Thibodeaux, C. J.; van der Donk, W.A.* “Converging on a mechanism for choline degradation” Proc. Natl. Acad. Sci. U.S.A., 2012, 52, 21184–21185. PMCID: PMC3535664
187. Arnison, P. et al.; van der Donk, W.A.* “Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products: Overview and Recommendations for a Universal Nomenclature” Nat. Prod. Rep. 2013, 30, 108-160. PMCID: PMC3954855
186. Zhang, Q.; Yu, Y.; Vélasquez, J. E.; van der Donk, W. A.* “Evolution of Lanthipeptide Synthetases” Proc. Natl. Acad. Sci. U.S.A., 2012, 109, 18361-18366. PMCID: PMC3494888
185. Shi, Y.: Bueno, A; van der Donk, W.A.* “Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli” Chem. Comm. 2012, 48, 10966-10968. PMCID: PMC3485686
184. Cooke, H.A.; Peck, S.C.; Evans, B.S.; van der Donk, W.A.* “Mechanistic Investigation of Methylphosphonate Synthase, a Non-Heme Iron-Dependent Oxygenase” J. Am.Chem. Soc., 2012, 134, 15660-15663. PMCID: PMC3458437
183. Thibodeaux, G.; van der Donk, W.A.* “An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase” Chem. Comm. 2012, 48, 10615-10617. PMCID: PMC3475617
182. Knerr, P.J.; Oman, T.J.; Garcia de Gonzalo, C.; Lupoli,T.J. Walker S.; van der Donk, W. A.* “Non-Proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation” ACS Chem. Biol. 2012, 7, 1791-1795. PMCID: PMC3501146
181. Zhang, Q.; van der Donk, W.A.* “Catalytic promiscuity of a bacterial α-N-methyltransferase” FEBS Lett. 2012, 588, 3391-3397. PMCID: PMC3462432
180. Metcalf, W.W.*; Griffin, B.M.; Cicchillo, R.M.; Gao, J.; Janga, S.C.; Cooke, H.A.; Circello, B.T.; Evans; B.S.; Martens-Habbena, W.; Stahl, D.A.; van der Donk, W.A.* “Synthesis of methylphosphonic acid by abundant marine microbes: a source for methane in the aerobic ocean” Science 2012, 337, 1104-1107. PMCID: PMC3466329
179. Wang, H.; van der Donk, W.A.* “Biosynthesis of the Class III Lantipeptide Catenulipeptin” ACS Chem. Biol. 2012, 7, 1529-1535. PMCID: PMC3448297
178. Peck, S.C.; Gao, J.; van der Donk, W.A.* “Discovery and Biosynthesis of Phosphonate and Phosphinate Natural Products” Methods Enzymol. 2012, 516, 101-123 (special volume on natural product biosynthesis edited by Sir David Hopwood).
177. Zou, Y.; Zhang, H.; Brunzelle, J.S.; Johannes, T.W.; Woodyer, R.; Hung, J.E.; Nair, N.; van der Donk, W.A.; Zhao, H.; Nair, S.K.* “Crystal Structures of Phosphite Dehydrogenase Provide Insights into Nicotinamide Cofactor Regeneration” Biochemistry 2012, 51, 4263-4270.
176. Kim, S.Y.; Ju, K.-S.; Metcalf, W.W.; Evans, B.S.; Kuzuyama, T.; van der Donk, W.A.* “Different Biosynthetic Pathways to Fosfomycin in Pseudomonas syringae and Streptomyces” Antimicrob. Agents Chemother. 2012, 56, 4175-4183. PMCID: PMC3421606
175. Knerr, P.J.; van der Donk, W. A.* “Chemical Synthesis and Biological Activity of Analogues of the Lantibiotic Epilancin 15X” J. Am. Chem. Soc. 2012, 134, 7648-7651. PMCID: PMC3349288
174. Hung, J.E.; Fogle, E.J.; Christman, H.D.; Johannes, T.W.; Zhao, H.; Metcalf, W.W.; van der Donk, W.A.* “Investigation of the Role of Arg301 Identified in the X-ray Structure of Phosphite Dehydrogenase” Biochemistry 2012, 51, 4254-4262. PMCID: PMC3361975
173. Tang, W.; van der Donk, W. A.* “Structural characterization of selected prochlorosins – a novel class of lantipeptides produced by planktonic marine cyanobacteria” Biochemistry 2012, 51, 4271-4279. PMCID: PMC3361976
172. Garg, N.; Tang, W.; Goto, Y.; van der Donk, W.A.* “Lantibiotics from Geobacillus thermodenitrificans” Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 5241-5246. PMCID: PMC3325677
171. Oman, T.J.; Knerr, P.J.; Bindman, N.A.; Velásquez, J.E.; van der Donk, W.A.* “An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate” J. Am. Chem. Soc. 2012, 134, 6952-6955. PMCID: PMC3350211
170. Knerr, P.J.; van der Donk, W.A.* “Discovery, Biosynthesis and Engineering of Lantipeptides” Ann. Rev. Biochem. 2012, 81, 479-505.
169. Peck, S.C.; Kim, S.Y.; Evans, B.S.; van der Donk, W.A.* “Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis” Med. Chem. Commun. 2012, 3, 967-970. PMCID: PMC3764496
168. Zhang, Q.; van der Donk, W.A.* “Answers to the carbon-phosphorus lyase conundrum” ChemBioChem 2012, 13, 627-629. PMCID: PMC3206492

2011


167. Zhang, Q.; van der Donk, W.A.*; Liu, W.* “Radical-mediated enzymatic methylation: a tale of two SAMs” Acc. Chem. Res. 2011, 45, 555-564. PMCID: PMC3328197
166. Oman, T.O.; Lupoli, T.J.; Wang, T-S. A.; Kahne, D.; Walker, S.*; van der Donk, W.A.* “Haloduracin  Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry” J. Am. Chem. Soc. 2011, 133, 17544-17547. PMCID: PMC3206492
165. Agarwal, V.; Borisova, S.A.; Metcalf, W.W.; van der Donk, W.A.*; Nair, S.K. * “Structural and Mechanistic Insights into C-P Bond Hydrolysis by Phosphonoacetate Hydrolase” Chem. Biol. 2011, 18, 1230-1240. PMCID: PMC4321816
164. Wang, H.; van der Donk, W.A.* “Substrate selectivity of the S-glycosyltransferase from sublancin biosynthesis” J. Am. Chem. Soc. 2011, 133, 16394–16397. PMCID: PMC3191765
163. DeSieno, M.A.; van der Donk, W.A.; Zhao, H.* “Characterization and Application of the Fe(II) and α-Ketoglutarate Dependent Hydroxylase FrbJ” Chem. Comm. 2011, 47, 10025-10027. PMCID: PMC4091617
162. Velásquez, J.E.; Zhang, X.; van der Donk, W.A.* “Biosynthesis of the Antimicrobial Peptide Epilancin 15X and its Unusual N-terminal Lactate Moiety” Chem. Biol. 2011, 18, 857-867. PMCID: PMC3161514
161. Ökesli, A.; Cooper, L.E.; Fogle, E.J.; van der Donk, W.A.* “Nine Posttranslational Modifications During the Biosynthesis of Cinnamycin” J. Am. Chem. Soc. 2011, 133, 13753–13760. PMCID: PMC3163434
160. Peck, S.C.; Cooke, H.A.; Cicchillo, R.M.; Nair, S.K.; van der Donk W.A.* “Mechanism and Substrate Recognition of HydroxyethylphosphonateDioxygenase” Biochemistry 2011, 50, 6598-6605. PMCID: PMC3143709
159. Borisova, S.A.; Christman, H.D.; Mourey-Metcalf, M.E.; Zulkepli, N.A.; Zhang, J.K.; van der Donk, W.A.; Metcalf, W.W.* “Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021” J. Biol. Chem. 2011, 286, 22283-22290. PMCID: PMC3121374
158. Knerr, P.J.; Tzekou, A.; Ricklin, D.; Qu, H.; van der Donk, W.A.*; Lambris, J.D.* “Synthesis and Activity of Thioether-containing Analogues of the Complement Inhibitor Compstatin” ACS Chem. Biol. 2011, 6, 753-760. PMCID: PMC3137721
157. Gut, I.M.; Blanke, S.R. *; van der Donk, W.A.* “Mechanism of Nisin Inhibition of Bacillus anthracis Spore Outgrowth” ACS Chem. Biol. 2011, 6, 744-752. PMCID: PMC3178273
156. Circello, B.T.; Miller, C.G.; Lee, J.-H.; van der Donk,W.A.; Metcalf, W.W.* “The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica” Antimicrob. Agents Chemother. 2011, 55, 3357-3362. PMCID: PMC3122408
155. Whitteck, J.T.; Malova, P.; Peck, S.C.; Cicchillo, R.M.; Hammerschmidt, F.*; van der Donk, W.A.* “On the Stereochemistry of 2-Hydroxyethylphosphonate Dioxygenase” J. Am. Chem. Soc. 2011, 133, 4236-4239. PMCID: PMC3069692
154. Gut, I.M.; Tamilselvam, B.; Prouty, A.M.; Stojkovic, B.; Czeschin, S.; van der Donk, W.A.*; Blanke S.R.* “Bacillus anthracis spore interactions with mammalian cells: Relationship between germination state and the outcome of in vitro infections” BMC Microbiol. 2011, 11, 46. PMCID: PMC3060849
153. Goto, Y.; Ökesli, A.; van der Donk, W.A.* “Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL Lanthioninesynthetase family” Biochemistry 2011, 50, 891-898. PMCID: PMC3031989
152. Oman, T.J.; Boetcher, J.D.; Wang, H.; Okalibe, X.N.; van der Donk, W.A.* “Sublancin is not a Lantibiotic but an S-linked Glycopeptide” Nat. Chem. Biol. 2011, 2, 78-80. PMCID: PMC3060661
151. Wu, G.; Lü, J.-M.; Kulmacz, R.J. van der Donk, W.A.; Tsai, A.L.* “Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects” J. Inorg. Biochem. 2011, 105, 382-390. PMCID: PMC3049311
150. Lü, J.-M.; Rogge, C.E.; Wu, G.; Kulmacz, R.J. van der Donk, W.A.; Tsai, A.L.* “Cyclooxygenase Reaction Mechanism of PHS. Evidence for a Reversible Transition Between A Pentadienyl Radical and a New Tyrosyl Radical by Nitric Oxide Trapping” J. Inorg. Biochem. 2011, 105, 356-365. PMCID: PMC3053578
149. Tsai, A.L.*; Wu, G.; Rogge, C.E.; Lü, J.-M.; Peng, S.; van der Donk, W.A.; Palmer, G.; Gerfen, G.J.; Kulmacz, R.J. “Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin h synthase-1 and -2” J. Inorg. Biochem. 2011, 105, 366-74. PMCID: PMC3073652
148. Shi, Y.; Yang, X.; Garg, N.; van der Donk, W.A.* “Production of Lantipeptides in Escherichia coli” J. Am. Chem. Soc., 2011, 133, 2338-2341. PMCID: PMC3044485
147. Velásquez, J.E.; and van der Donk, W.A.* “Genome Mining for Ribosomally Synthesized Natural Products” Curr. Opin. Chem. Biol. 2011, 15, 11-21. PMCID: PMC3090663
146. Bindman, N.; Merkx R.; Koehler, R.; Herrman, N.; van der Donk, W.A.* “Photochemical Cleavage of Leader Peptides” Chem. Comm. 2010, 46, 8935-8937. PMCID: PMC3100556
145. Nair, S.K. and van der Donk, W.A.* “Structure and Mechanism of Enzymes Involved in Biosynthesis and Breakdown of the Phosphonates Fosfomycin, Dehydrophos, and Phosphinothricin” Arch. Biochem. Biophys. 2011, 505, 13-21. PMCID: PMC3040005

2010


144. van der Donk, W.A.; Krebs, C.; Bollinger Jr., J.M. “Substrate Activation by Iron Superoxo Intermediates” Curr. Opin. Struct. Biol. 2010, 20, 673-683. PMCID: PMC3030196
143. Kuemin, M.; van der Donk, W.A.* “Structure-activity relationships of the phosphonate antibiotic dehydrophos” Chem. Comm. 2010, 46, 7694-7696. PMCID: PMC3109733
142. Lee, J.H; Bae, B.; Kuemin, M.; Circello, B.T. Metcalf, W.W.; Nair, S.K.; van der Donk W.A.* “Characterization and Structure of DhpI, a Phosphonate O-Methyltransferase Involved in Dehydrophos Biosynthesis” Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 17557-17562. PMCID: PMC2955109
141. Clark, K.M.; Yu, Y.; Marshall, N.; Sieracki, N.; Nilges, M.; Blackburn, N.; van der Donk, W.A.*; Lu, Y.* “Transforming a Blue Copper into a Red Copper Protein: Engineering Cysteine and Homocysteine into the Axial Position of Azurin using Site-Directed Mutagenesis and Expressed Protein Ligation” J. Am. Chem. Soc. 2010 132, 10093-10101. PMCID: PMC2929572
140. Li, B.; Sher, D.; Kelly, L.; Shi, Y.; Huang, K.; Knerr, P.J.; Joewono, I.; Rusch, D.; Chisholm, S.W.*; van der Donk. W.A.*, “Catalytic Promiscuity in the Biosynthesis of Cyclic Peptide Secondary Metabolites in Planktonic Marine Cyanobacteria” Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 10430-10435. PMCID: PMC2890784
139. Circello B.T.; Eliot A.C.; Lee, J.H.; van der Donk, W.A.; Metcalf, W.W.* “Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster” Chem. Biol. 2010, 17, 402-411. PMCID: PMC2888486
138. Goto, Y.; Li, B.; Claesen, J.; Shi, Y.; Bibb, M.J.; van der Donk, W.A.* “Discovery of Unique Lantibiotic Synthetases Reveals Mechanistic and Evoluntionary Insights” PLoS Biol. 2010, 8, e1000339. PMCID: PMC2843593
137. Borisova, S.A.; Circello B.T.; van der Donk, W.A.*; Metcalf, W.W.* “Biosynthesis of Rhizocticins, Antifungal Phosphonate Oligopeptides Produced by Bacillus subtilis ATCC6633” Chem. Biol. 2010,1, 28-37. PMCID: PMC2819989
136. Oman, T.; van der Donk, W.A.* “Follow the Leader: the Use of Leader Peptides to Guide Natural Product Biosynthesis” Nat. Chem. Biol. 2010, 1, 9-18. PMCID: PMC3799897
135. Cooper, L.E.; Li, B.; van der Donk, W.A.* “Biosynthesis and Mode of Action of Lantibiotics” in Comprehensive Natural Products II Chemistry and Biology, Eds. Mander, L.; Liu, H.-w., Elsevier: Oxford, 2010, 5, 217-256.

2009


134. Whitteck, J.T.; Cicchillo, R.M.; van der Donk, W.A.* “Hydroperoxylation by Hydroxyethyl-phosphonate Dioxygenase” J. Am. Chem. Soc. 2009, 131, 16225. PMCID: PMC2773148
133. Wecksler, A.T.; Kenyon, V.; Garcia, N.K.; Deschamps, J.D.; van der Donk, W.A.; Holman, T.R.* “Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-Lipoxygenase-2” Biochemistry 2009, 36, 8721-30. PMCID: PMC2746553
132. Oman, T.; van der Donk, W.A.* “Insights into the Mode of Action of the Two-Component Lantibiotic Haloduracin” ACS Chem. Biol. 2009, 10, 865-74.PMCID: PMC2812937
131. Levengood, M.R.; Knerr, P.J.; Oman, T.J.; van der Donk, W.A.* “In Vitro Mutasynthesis of Lantibiotic Analogs Containing Nonproteinogenic Amino Acids” J. Am. Chem. Soc. 2009, 131, 12024-25. PMCID: PMC2732204
130. Lee, M.V.; Ihnken, L.A.F.; You, Y.O.; McClerren, A.L.; van der Donk, W.A.*; Kelleher, N.L.* “Distributive and Directional Behavior of Lantibiotic Synthetases Revealed by High-Resolution Tandem Mass Spectrometry” J. Am. Chem. Soc. 2009, 131, 12258-64. PMCID: PMC2735757
129. Clark, K.M.; van der Donk, W.A.*; Lu, Y.* “Expressed Protein Ligation for Metalloprotein Design and Engineering”Methods Enzymol. 2009, 462, 98-115. PMCID: PMC2780537
128. Zhang, X.; van der Donk, W.A.* “Using Expressed Protein Ligation to Probe the Substrate Specificity of Lantibiotic Synthetases” Methods Enzymol. 2009, 462, 117-134. PMCID: PMC2780537
127. Lee, J.; Evans, B.S.; Li, G.; Kelleher, N.L.*; van der Donk, W.A.* “In vitro Characterization of a Heterologously Expressed Non-Ribosomal Peptide Synthetase Involved in Phosphinothricin Tripeptide Biosynthesis” Biochemistry 2009, 48, 5054-5056. PMCID: PMC2709985
126. Wecksler, A.T.; Jacquot, C.; van der Donk, W.A.*; Holman, T.R.* “Mechanistic Investigations of Human Reticulocyte15- and Platelet 12-Lipoxygenases with Arachidonic Acid” Biochemistry 2009, 48, 6259-67. PMCID: PMC2935259
125. Cicchillo, R.M.; Zhang, H.; Blodgett, J.A.V.; Whitteck, J.T.; Li, G.; Nair, S.K.*; van der Donk, W.A.*; Metcalf, W.W.* “An Unusual Carbon-Carbon Bond Cleavage Reaction During Phosphinothricin Biosynthesis” Nature 2009, 459, 871-874. PMCID: PMC2874955
124. You, Y.O.; Levengood, M. R.; Furgerson Ihnken, L.A.; Knowlton, A.K., van der Donk, W.A.* “Lacticin 481 Synthetase as a General Ser/Thr Kinase” ACS Chem. Biol. 2009, 4, 379-385. PMCID: PMC2709986
123. Li, B.; Cooper, L.E.; van der Donk, W.A.* “In vitro Studies of Lantibiotic Biosynthesis” Methods Enzymol. 2009, 458, 533-558.
122. Levengood, M.R.; Kerwood, C.C.; Chatterjee, C.; van der Donk, W.A.* “Investigation of the Substrate Specificity of Lacticin 481 Synthetase Using Nonproteinogenic Amino Acids” ChemBioChem 2009, 10, 911-919. PMCID: PMC2737179
121. Metcalf, W.W.; van der Donk, W. A. “Biosynthesis of Phosphonic and Phosphinic Acid Natural Products” Ann. Rev. Biochem. 2009, 78, 65-94. PMCID: PMC2729427

2008


120. Barry, A.N.; Clark, K.M.; Otoikhian, A.; van der Donk, W.A.; Blackburn, N.* “Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase” Biochemistry 2008, 47, 13074-83. PMCID: PMC2645929
119. Jacquot, C.; McGinley, C.M.; Plata, E.; van der Donk, W.A.* “Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases” Org. Biomol. Chem. 2008, 6, 4242-52. PMCID: PMC2883171
118. Gut, I.M.; Prouty, A.M.; Ballard, J. D.; van der Donk, W.A.*; Blanke, S.R.* “Inhibition of Bacillus anthracis Spore Outgrowth by Nisin” Antimicrob. Agents Chemother. 2008, 52, 4281-8. PMCID: PMC2592879
117. Cooper, L.E.; McClerren, A.L; Chary, A.; van der Donk, W.A.* “Structure-Activity Relationship Studies of the Two-Component Lantibiotic Haloduracin” Chem. Biol. 2008, 15, 1025-45. PMCID: PMC2633096
116. Jacquot, C.; Peng, S.; van der Donk, W.A.* “Kinetic Isotope Effects in the Oxidation of Arachidonic Acid by Soybean Lipoxygenase-1” Bioorg. Med. Chem. Lett. 2008, 18, 5959-62. PMCID: PMC2652760
115. Furgerson Ihnken, L.A.; Chatterjee, C.; van der Donk, W.A.* “In Vitro Reconstitution and Substrate Specificity of a Lantibiotic Protease”Biochemistry 2008, 47, 7352-7363. PMCID: PMC2574596
114. Patton, G.C.; Paul, M.; Cooper, L.E.; Chatterjee, C.; van der Donk, W.A.* “The Importance of the Leader Sequence for Directing Lanthionine Formation in Lacticin 481” Biochemistry 2008, 47 7342-7351. PMCID: PMC2574596
113. Jacquot, C.; Wecksler, A.T.; McGinley, C.M.; Segraves, E.N.; Holman, T.R.*; van der Donk, W.A.* “Isotope Sensitive Branching and Kinetic Isotope Effects in the Reaction of Deuterated Arachidonic Acids with Human 12- and 15-Lipoxygenases.” Biochemistry 2008, 47, 7295-7303. PMCID: PMC2574664
112. Shao, Z.; Blodgett, J.A.V.; Circello, B.T.; Eliot, A.C.; Woodyer, R.; Li, G.; van der Donk, W.A., Metcalf, W.W.; Zhao, H.* “Biosynthesis of 2-Hydroxyethylphosphonate, an Unexpected Intermediate Common to Multiple Phosphonate Biosynthetic Pathways” J. Biol. Chem. 2008, 283, 23161-23168..PMCID: PMC2516978
111. Levengood, M.R.; van der Donk, W.A.* “Use of Lantibiotic Synthetases for the Preparation of Bioactive Constrained Peptides” Bioorg. Med. Chem. Lett. 2008, 18, 3025-3028. PMCID: PMC2452991
110. Furgerson, L.A.; van der Donk, W.A* “Lantibiotics, Biosynthesis, and Mode of Action” in Encyclopedia of Chemical Biology, Begley, T.P., Ed. Wiley Blackwell, 2009.

2007


109. Fogle, E.J.; van der Donk, W.A.* “Pre-Steady State Studies of Phosphite Dehydrogenase Demonstrate that Hydride Transfer is Fully Rate-Limiting” Biochemistry 2007, 46, 13101-8. PMCID: PMC2517116
108. Whitteck, J.T.; Ni, W.; Griffin, B.M.; Eliot, A.C.; Thomas, P.M.; Kelleher, N.M.; Metcalf, B.W.; van der Donk, W.A.* “Reassignment of the Structure of the Antibiotic A53868 Reveals an Unusual Amino Dehydrophosphonic Acid” Angew. Chem. Intl. Ed. Engl. 2007, 46, 9089-9092.
107. van der Donk, W.A.; Booker, S.J. “Never Stop Questioning” Curr. Opin. Chem. Biol. 2007, 11, 527-528.
106. Levengood, M.R.; Patton, G.C.; van der Donk, W.A.* “The Leader Peptide is not Required for Post-translational Modification by Lacticin 481 Synthetase”J. Am. Chem. Soc. 2007, 129, 10314-5. PMCID: PMC2492579
105. Zhang, X.; Ni, W.; van der Donk, W.A.* “On the Regioselectivity of Thioether Formation by Lacticin 481 Synthetase” Org. Lett. 2007, 9, 3343-6. PMCID: PMC2517117
104. Willey, J.M.*; van der Donk, W.A.* “Lantibiotics: Peptides of Diverse Structure and Function” Ann. Rev. Microbiol. 2007, 61, 477.
103. Blodgett, J.A.V.; Thomas, P.M.; Li, G.; Velasquez, J.E.; van der Donk, W.A.; Kelleher, N.L.; Metcalf, W.W.* “Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide” Nat. Chem. Biol. 2007, 3, 480-485. PMCID: PMC4313788
102. McGinley, C.M.; Jacquot, C.; van der Donk, W.A.* “Synthesis of 7-Thiaarachidonic Acid as a Mechanistic Probe of Prostaglandin H Synthase-2” Bioorg. Med. ChemLett. 2007, 17, 4049-52. PMCID: PMC2040112
101. Li, B.; van der Donk, W.A.* “Identification of Essential catalytic Residues of the Nisin Cyclase NisC” J. Biol. Chem. 2007, 282, 21169-21175. NIHMS ID: pending submission by publisher.
100. Paul, M; Patton, G.C.; van der Donk, W.A.* “Mutants of the Zinc Ligands of Lacticin 481 Synthetase Retain Dehydration Activity but Have Impaired Cyclization Activity” Biochemistry 2007, 46, 6268-76. PMCID: PMC2517114
99. You, Y.O.; van der Donk, W.A.* “Mechanistic Investigations of the Dehydration Reaction of Lacticin 481 Synthetase Using Site-Directed Mutagenesis” Biochemistry 2007, 46, 5991-6000.
PMCID: PMC2517115
98. Zhang, X.; van der Donk, W.A.* “On the Substrate Specificity of Dehydration by Lacticin 481 Synthetase” J. Am. Chem. Soc. 2007, 129, 2212-2213. PMCID: PMC2517113
97. Li, G.; van der Donk, W.A.* “Efficient Synthesis of Suitably Protected β-Difluoroalanine and γ-Difluorothreonine from L-Ascorbic Acid” Org. Lett. 2007, 9, 41-44. PMCID: PMC2593874.
96. Levengood, M.; van der Donk, W.A.* “Dehydroalanine-containing peptides: preparation from Phenylselenocysteine and utility in convergent ligation strategies” Nat. Protocols 2007, 1, 3001-3010.
95. Woodyer, R.; Li, G.; Zhao, H.*; van der Donk, W.A.* “New Insight into the Mechanism of Methyl Transfer during the Biosynthesis of Fosfomycin” Chem. Comm. 2007, 359-361.

2006


94. Woodyer, R. D.; Shao, Z.; Metcalf, W. M.; van der Donk, W. A.*; Zhao, H.* “Heterologous Production of Fosfomycin and Identification of the Minimal Biosynthetic Gene Cluster” Chem. Biol. 2006, 13, 1171-1182.
93. van der Donk, W.A.* “Rings, Radicals, and Regeneration: the Early Years of a Bioorganic Laboratory” J. Org. Chem. 2006, 71, 9561-9571. NIHMS: 61603 PMCID: 2519235
92. Chatterjee, C.; Patton, G. C.; Cooper, L.; Paul, M.; Xie, L.; Ni, W.; van der Donk, W. A.* “Engineering Dehydro Amino Acids and Thioethers into Peptides using Lacticin 481 Synthetase” Chem & Biol. 2006, 13, 1109-17.
91. McClerren,A.L.; Cooper, L.E.; Quan, C.; Thomas, P.M.; Kelleher, N.L.; van der Donk, W.A.* “Discovery and in vitro Biosynthesis of Haloduracin, a New Two-component Lantibiotic” Proc. Natl. Acad. Sci. USA 2006, 103, 17243-17248.
90. Relyea, H.A.; van der Donk, W.A.* “Nature’s Way to Make the Lantibiotics” J. Chem. Educ., 2006, 83, 1769.
89. Liu, W.; Wang, L.H.; Pavol, F.; Hayashi, Y.; McGinley, C.M.; van der Donk, W.A.; Kulmacz, R.* “Arabidopsis thaliana Fatty Acid Alpha-dioxygenase-1: Evaluation of Substrates, Inhibitors, and Amino Terminal Function” Plant Physiol. Biochem. 2006, 44, 284-293.
88. van der Donk, W.A. “Lighting up the nascent cell wall” ACS Chem Biol. 2006, 1, 425–428.
87. McGinley, C. M.; van der Donk, W. A.* “Synthesis of Site-Specifically DeuteratedArachidonic Acid Derivatives Containing a Remote Tritium Radiolabel” J. Label. Cmpd. Radiopharm. 2006, 49, 545-558.
86. Pesavento, R.P.; Pratt, D.A.; Jeffers, J.; van der Donk, W.A.* “Model Studies of the CuB Site of Cytochrome c Oxidase Utilizing a Zn(II) Complex Containing an Imidazole-Phenol Cross-Linked Ligand” Dalton Trans. 2006, 3326-3337.
85. Li, B.; Yu, J.-P. J.; Brunzelle, J. S.; Moll, G. N.; van der Donk, W. A.*; Nair, S. K.* “Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin Biosynthesis” Science, 2006, 311, 1464.
84. Miller, L. M.; Chatterjee, C.; van der Donk, W. A.; Kelleher, N. L.* Dehydration Activity of Lacticin 481 Synthetase is Highly Processive” J. Am. Chem. Soc. 2006, 128, 1420-1421. PMCID: PMC2532561
83. McGinley, C.M.; van der Donk, W.A.* “Vitamin B12 Catalyzed Radical Cyclizations of Arylalkenes” Synlett, 2006, 211-214.
82. Pratt, D.A.; van der Donk, W.A.* “On the Role of Alkylcobalamins in the Vitamin B12-Catalyzed Reductive Dehalogenation of Perchloroethylene and Trichloroethylene” Chem. Commun. 2006, 558-560.
81. Woodyer, R.; van der Donk, W.A. *; Zhao, H. * “Optimizing a Biocatalyst for Improved NAD(P)H Regeneration: Directed Evolution of Phosphite Dehydrogenase” Comb. Chem. HighThroughput Screen. 2006, 9, 237-245.

2005


80. van der Donk, W.A. “The protein Modification Repertoire” Nature Chem. Biol. 2005, 1, 243.
79. Chatterjee, C.; Miller, L. M.; Leung, Y. L.; Xie, L.; Yi, M.; Kelleher, N.L.; van der Donk, W.A.* “Lacticin 481 Synthetase Phosphorylates its Substrate during Lantibiotic Production” J. Am. Chem. Soc. 2005, 127, 15332-15333.
78. Ide, N.D.; Galonić, D.P.; van der Donk, W.A.; Gin, D.Y.* “Conjugation of Selenols with Aziridine-2-Carboxylic Acid-Containing Peptides” Synlett. 2005, 2011-2014.
77. Patton, G.C.; van der Donk, W.A.* “New Developments in Lantibiotic Biosynthesis and Mode of Action” invited review for Curr. Opin.Microbiol. 2005, 8, 543-551.
76. Zhang, X.; Ni, W.; van der Donk, W.A.* “Synthesis of Nonproteinogenic Amino Acids to Probe Lantibiotic Biosynthesis” J. Org. Chem. 2005, 70, 6685-92. NIHMS: 61603PMCID: 2525736
75. Woodyer, R.; Zhao, H. *; van der Donk, W.A. * “Mechanistic Investigations of a Highly Active Phosphite Dehydrogenase Mutant with Relaxed Cofactor Specificity” FEBS J. 2005, 272, 3816-3827.
74. Pratt, D.A.; Pesavento, R.P.; van der Donk, W.A.* “Model Studies of the Histidine-Tyrosine Cross-Link in Cytochrome c Oxidase Reveal the Promiscuous Nature of Imidazole as a Substituent” Org. Lett. 2005, 7, 2735-2738.
73. Galonić, D. P.; Ide, N. D.; van der Donk, W. A.;* Gin, D. Y. * “Aziridine-2-Carboxylic Acid Containing Peptides.Application to Solution- and Solid-Phase Convergent Site-Selective Peptide Modification” J. Am. Chem. Soc. 2005, 127, 7359-69.
72. Relyea, H.A.; Wheatley, J. L.; Woodyer,R.; Rimkus,S.; van der Donk, W.A.* “Inhibition and pH Dependence of Phosphite Dehydrogenase” Biochemistry 2005, 44, 6640-6649.
71. Woodyer,R.; Wheatley, J. L. ;Relyea, H.A.; Rimkus,S.; van der Donk, W.A.* “Site-Directed Mutagenesis of Active Site Residues of Phosphite Dehydrogenase” Biochemistry 2005, 44, 4765-4774.
70. Relyea, H.A.; van der Donk, W.A.* “Mechanism and Applications of Phosphite Dehydrogenase” Bioorg. Chem. 2005, 33, 171-89.
69. Woodyer, R.; Simurdiak, M. ; van der Donk, W.A. *; Zhao, H. * “Functional Heterologous Expression of a Highly Active Xylose Reductase from Neurosporacrassa” Appl. Environ. Microbiol. 2005, 71, 1642-1647. PMC ID: PMC1065158
68. McCauley, K.M.; Pratt, D.A.; Wilson, S. R.; Shey, J.; Burkey, T.J.; van der Donk, W.A.* “Properties and Reactivity of Chlorovinylcobalamin and Vinylcobalamin and Their Implications for Vitamin B12-Catalyzed Reductive Dechlorination of Chlorinated Alkenes” J. Am. Chem. Soc. 2005, 127, 1126-1136.
67. Chatterjee, C. Paul, M.; Xie, L.; van der Donk, W.A.* “Biosynthesis and Mode of Action of Lantibiotics.” Chem. Rev. 2005, 105, 633-684. Invited review for special issue on antibiotics.
66. Pratt, D. A.*, van der Donk, W.A.* “Theoretical Investigations into the Intermediacy of Chlorinated Vinyl Cobalamins in the Reductive Dehalogenation of Chlorinated Ethylenes.” J. Am. Chem. Soc. 2005, 127, 384-396.
65. Galonić, D.; van der Donk, W.A.*; Gin, D.Y.* “Convergent Site-Selective Ligation with Aziridine-2-Carboxylic Acid Containing Peptides” J. Am. Chem. Soc. 2004, 126, 12712-12713.
64. Xie, L.; van der Donk, W.A.* “Post-Translational Modifications during Lantibiotic Biosynthesis” Invited review Curr. Opin. Chem. Biol. 2004, 8, 498-507.
63. Paul, M.; van der Donk, W.A.* “Chemical and Enzymatic Synthesis of Lanthionines” Minirev. Org. Chem. 2005, 1, 23-37.

2004


62. Ralle, M.; Berry, S. M.; Gieselman, M.D.; Nilges, M.J.; van der Donk, W.A.; Lu, Y.; Blackburn, N. J.* “The Selenocysteine Substituted Blue Copper Center. Spectroscopic Investigations of Cys112SeCys Pseudomonas Aeruginosa Azurin”J. Am. Chem. Soc. 2004, 126, 7244-7256.
61. Xie, L.; Miller, L.; Chatterjee, C.; Averin, O.; Kelleher, N.L.;* van der Donk, W.A.* “Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity” Science 2004, 303, 679-681.
60. Peng, S.; McGinley, C.M.; .van der Donk, W.A.* “Synthesis of Site-Specifically Labeled Arachidonic Acids as Mechanistic Probes for Prostaglandin H Synthase” Org. Lett. 2004, 6, 349-352.

2003


59. McGinley, C.M.; van der Donk, W.A.* “Enzymatic Hydrogen Atom Abstraction from Polyunsaturated Fatty Acids” Chem. Commun. 2003, 2843-2846.
58. Okeley, N.M.; Paul, M.; Stasser, J.P.; Blackburn, N.J.;* van der Donk, W.A.* “SpaC and NisC, the Cyclases Involved in Subtilin and Nisin Biosynthesis, are Zinc Proteins” Biochemistry 2003, 42, 13613-13624.
57. Galonić, D. P.; van der Donk, W.A.*; Gin, D.Y.* “Oligosaccharide-Peptide Ligation of GlycosylThiolates with Dehydropeptides. Synthesis of S-Linked Mucin Glycopeptide Conjugates” Chem. – Eur. J. 2003, 24, 5997-6006.
56. Zhao, H. *; van der Donk, W.A.* “Regeneration of Cofactors for Use in Biocatalysis” Curr. Opin. Biotechnol. 2003, 14, 583-589.
55. Woodyer, R.; van der Donk, W. A.*; Zhao, H.* “Relaxing the Nicotinamide Cofactor Specificity of Phosphite Dehydrogenase by Rational Design” Biochemistry 2003, 42, 11604-11614.
54. Zhu, Y.; Gieselman, M. D.; Zhou, H.; Averin, O.; van der Donk, W.A.* “Biomimetic studies on the mechanism of stereoselectivelanthionine formation” Org. Biomol. Chem. 2003, 1, 3304-3315.
53. Zhou, H.; Schmidt, D. M. Z.; Gerlt, J. A.*; van der Donk, W.A.* “Chemical and Enzymatic Synthesis of Fluorinated Dehydroalanine-Containing Peptide.” ChemBioChem, 2003, 1206-1215.
52. van der Donk, W.A.*; Zhao, H.* “Recent Developments in Pyridine Nucleotide Regeneration” Curr. Opin. Biotechnol. 2003, 14, 421-426.
51. Peng, S.; van der Donk, W.A.* “An Unusual Isotope Effect on Substrate Inhibition in the Oxidation of Arachidonic Acid by Lipoxygenase” J. Am. Chem. Soc. 2003, 125, 8988-8989.
50. Kulmacz, R.J.*; van der Donk, W.A.; Tsai, A.-L. “Comparison of the Properties of Prostaglandin H Synthase-1 and –2” Progr. Lipid Res. 2003, 42, 377-404.
49. Blomberg, M. L.*; Blomberg, M.R.A.; Siegbahn, P. E. M.; van der Donk, W. A.; Tsai, A.-L. “A Quantum Chemical Study of the Synthesis of Prostaglandin G2 by the Cyclooxygenase Active Site in Prostaglandin Endoperoxide H Synthase 1” J. Phys. Chem. B, 2003, 107, 3297-3308.
48. McCauley, K.M.; Wilson, S.S.R.; van der Donk, W.A* “Characterization of Chlorovinylcobalamin, a Putative Intermediate in Reductive Degradation of Chlorinated Ethylenes” J. Am. Chem. Soc. 2003, 125, 4410-4411.

2002


47. van der Donk, W.A.*; Tsai, A.-L.; Kulmacz, R.J. “The Cyclooxygenase Reaction Mechanism.” Invited Current Topics article in Biochemistry 2002, 41, 15451-15458.
46. Hellwig, P.*; Pfitzner, U.; Behr, J.; Rost;, B. Pesavento, R.P.; van der Donk, W.A.; Gennis, R.B.; Michel, H.; Ludwig, B.; Mantele, W. “Vibrational modes of tyrosines in cytochrome c oxidase from Paracoccus denitrificans: FTIR and electrochemical studies on Tyr-D4-labeled and on Tyr280His and Tyr35Phe mutant enzymes” Biochemistry 2002, 41, 9116-9125.
45. McCauley, K.M.; Wilson, S.S.R.; van der Donk, W.A.* “Dichloroacetylene is not a precursor to dichlorinatedvinylcobaloxime and vinylcobalamin in the cobalt-catalyzed dechlorination of perchloroethylene” Inorg. Chem. 2002, 41, 5844-5848.
44. Nonnenberg, C.; van der Donk, W.A.*; Zipse, Z.* “Reductive Dechlorination of Trichloroethylene –A Computational Study” J. Phys. Chem. A 2002, 106, 8708-8715.
43. Peng, S.; Okeley, N.M.; Tsai, A.L.; Wu, G.; Kulmacz, R.J.; van der Donk, W.A.* “Synthesis of Isotopically Labeled Arachidonic Acids as Probes for the Reaction Mechanism of Prostaglandin Synthase” J. Am. Chem. Soc. 2002, 124, 10785-10796.
42. Xie, L.; Chatterjee, C.; Balsara, R.; Okeley, N.M.; van der Donk, W.A.* “Heterologous Expression and Purification of SpaB, the Dehydratase Involved in Subtilin Biosynthesis” Biochem.Biophys. Res. Commun. 2002, 295, 952-957.
41. Vrtis, J.M.; White, A.K.; Metcalf, W.W.; van der Donk, W.A.* “A New and Efficient NADH Regeneration System” Angew.Chemie Intl. Ed. Engl. 2002, 41, 3257-3259.
40. Tsai, A. L.; Palmer, G.; Wu, G.; Peng, S.; Okeley, N. M.; van der Donk, W. A.; Kulmacz, R. J. J. Biol. Chem. 2002, 277, 38311-38321.
39. Gieselman, M.; Zhu, Y.; Zhou, H.; Galonic, D.; van der Donk, W.A.* “Selenocysteine Derivatives for Chemoselective Ligations” ChemBioChem 2002, 3, 709-716.
38. Zhou, H.; van der Donk, W.A.* “Biomimetic Synthesis of Methyllanthionine.” Org. Lett. 2002, 4, 1335-1338.
37. Berry, S.; Gieselman, M.D.; Nilges, M.J.; van der Donk, W.A.*; Lu, Y.* “An Engineered Azurin Variant Containing a Selenocysteine Copper Ligand” J. Am. Chem. Soc. 2002, 124, 2084-2085.
36. Shey, J.; McCauley, K.M.; Dearth, A.; Young, B.; van der Donk, W.A.* “A Novel Vitamin B12-Catalyzed Carbon-Carbon Bond Forming Reaction” J. Org. Chem. 2002, 67, 837-846.
35. McCauley, K.M.; Wilson, S.R.; van der Donk, W.A.* “Synthesis and Characterization of Chlorinated AlkenylCobaloximes to Probe the Mechanism of Vitamin B12 Catalyzed Dechlorination of Chloroalkenes” Inorg. Chem. 2002, 41, 393-404.

2001


34. Xie, L.; van der Donk, W.A.* “Homemade Cofactors- self-processing in galactose oxidase” Proc. Natl. Acad. Sci. USA 2001, 98, 12863-12865. PMC ID: PMC60785
33. Pesavento, R.; van der Donk, W.A.* “Tyrosyl Radical Cofactors.” Adv. Prot. Chem. 2001, 58, 317-385, Klinman, J.P.; Dove, J.E. Eds., Academic Press, San Diego.
32. Gieselman, M.; Xie, L.; van der Donk, W.A.* “Synthesis of a Selenocysteine Containing Peptide by Native Chemical Ligation” Org. Lett. 2001, 3, 1331-1334.
31. Zhu, Y.; van der Donk, W.A.* “Convergent Synthesis of Peptide Conjugates using Dehydroalanines for Chemoselective Ligations” Org. Lett. 2001, 3, 1189-1192.
30. Peng, S.; Okeley, N.M.; Tsai, A.-L.; Wu, G.; Kulmacz, R.; van der Donk, W.A.*, “Structural Characterization of a Pentadienyl Radical Intermediate Formed during Catalysis by Prostaglandin H Synthase 2” J. Am. Chem. Soc. 2001, 123, 3609-3610.
29. Vrtis, J.M.; White, A.; Metcalf, W.W.; van der Donk, W.A.*, “Phosphite Dehydrogenase: An unusual Phosphoryl Transfer Reaction” J. Am. Chem. Soc. 2001, 123, 2672-2673.
28. Zhou, H.; van der Donk, W.A.* “Synthesis of 2-Amino-3-fluoro-acrylic Acid Containing Peptides.” Org. Lett. 2001, 3, 593-596.

2000


27. Shey, J.; van der Donk, W.A.* “Mechanistic Studies on Vitamin B12-Catalyzed Dechlorination of Chlorinated Alkenes” J. Am. Chem. Soc. 2000, 122, 12403-12404.
26. Okeley, N.M.; Zhu, Y.; van der Donk, W.A.* “Facile Chemoselective Synthesis of Dehydroalanine-Containing Peptides” Org. Lett. 2000, 2, 3603-3606.
25. Okeley, N.M.; van der Donk, W.A.* “Novel Cofactors via Post-translational Modifications of Enzyme Active Sites” Chemistry & Biology 2000, 7, R159-R171.
24. McCauley, K.M.; Vrtis, J.M.; Dupont, J.; van der Donk, W.A.* “Insights into the Functional Role of the Tyrosine-Histidine Linkage in Cytochrome c Oxidase” J. Am. Chem. Soc. 2000, 122, 2403-2404.

Postdoctoral Research (Massachusetts Institute of Technology)
23. van der Donk, W.A.; Yu, G.; Perez, L.; Sanchez, R.; Stubbe, J.; Samano, V.; Robins, M.J. “Inactivation of RibonucleotideReductase from E. coli by Gemcitabine 5′-Diphosphate” Biochemistry 1998, 6419-6426.
22. van der Donk, W.A.; Gerfen, G.J.; Griffin, R.G.; Stubbe, J. “Definitive Evidence for 3’-Hydrogen Atom Abstraction DuringRibonucleotide Reduction” J. Am. Chem. Soc. 1998, 120, 4252-4253.
21. Stubbe, J.; van der Donk, W.A. “Protein Radicals in Catalysis” Chem. Rev. 1998, 98, 705-762.
20. Gerfen, G.J.; van der Donk, W.A.; Yu, G.; Farrar, C.; Griffin, R.G.; Stubbe, J.; McCarthy, J.R.; Matthews, D.P.; Jarvi, E.T. “Characterization of a Substrate Derived Radical Detected During the Inactivation of RibonucleotideReductase from Escherichia coli by 2′-Fluoromethylene-2′-deoxycytidine 5′-Diphosphate” J. Am. Chem. Soc. 1998, 120, 3823-3835.
19. van der Donk, W.A.; Zeng, C.; Biemann, K.; Stubbe, J.; Hanlon, A.; Kyte, J. “Identification of an Active Site Residue of the R1 Subunit of RibonucleotideReductase from E. coli: Characterization of Substrate Induced Polypeptide Cleavage by C225SR1” Biochemistry 1996, 35, 10058-10067.
18. van der Donk, W.A.; Yu, G.; Silva, D.J.; Stubbe, J.; McCarthy, J.R.; Matthews, D.P.; Jarvi, E.T.; Resvick, R.J.; Wagner, E. “Inactivation of RibonucleotideReductase by (E)-2′-Fluoromethylene-2′-deoxycytidine 5′-diphosphate: A Paradigm for Nucleotide Mechanism Based Inhibitors” Biochemistry 1996, 35, 8381-8391.
17. McCarthy, J.; Sunkara, P.; Matthews, D.; Bitonti, A.; Jarvi, E.; Sabol, J.; Resvick, R.; Huber, E.; van der Donk, W.; Yu, G.; Stubbe, J. “Design of a Fluoro Olefin Cytidine Nucleoside as a Bioprecursor of a Mechanism-Based Inhibitor of RibonucleotideReductase” ACS Symp. Ser.1996, 639, 246-264.
16. van der Donk, W.A.; Stubbe, J.; Gerfen, G.J.; Bellew, B.F.; Griffin, R.G. “EPR Investigation of the Inactivation of E. coliRibonucleotideReductase with 2′-Azido-2′-deoxyuridine 5′-Diphosphate: Evidence for the Involvement of the Thiyl Radical of C225-R1” J. Am. Chem. Soc. 1995, 117, 8908-8916.
15. Stubbe, J.; van der Donk, W.A. “RibonucleotideReductases: Radical Enzymes with Suicidal Tendencies” Chem. Biol. 1995, 2, 783-801.

Graduate Research (Rice University/Texas A&M University)
14. Porte, A.; van der Donk, W.A. Burgess, K. “A New and Efficient Synthesis of an Amino Acid for Preparing Phosphine-Functionalized Peptidomimetics” J. Org. Chem. 1998, 63, 5262-5264.
13. Burgess, K.; van der Donk, W.A. “Asymmetric Hydroboration” in Advanced Asymmetric Synthesis, Stephenson, G.R., Ed.; Chapman & Hall, London, 1996, 181-211.
12. Burgess, K.; van der Donk, W.A. “Tris(triphenylphosphine)rhodium(I) chloride” in Encyclopedia of Reagents for Organic Synthesis, Paquette, L., Ed.; Wiley, New York, 1995, 1253-1261.
11. Burgess, K.; van der Donk, W.A. “Transition-metal Catalyzed Reactions of Boron Hydrides” in Encyclopedia of Inorganic Chemistry; Vol. 3, King, R.B., Ed.; Wiley, New York, 1994, 1420.
10. Burgess, K.; van der Donk, W.A. “On Titanium Mediated Additions of Borohydride to Alkenes” J. Am. Chem. Soc. 1994, 116, 6561-6569.
9. Burgess, K.; van der Donk, W.A. “The Importance of Phosphine-to-Rhodium Ratios in EnantioselectiveHydroborations” Inorg.Chim.Acta 1994, 220, 93-98.
8. Burgess, K.; van der Donk, W.A. “On Titanium Catalyzed Additions of Borohydride to Alkenes”Organometallics 1994, 13, 3616-3620.
7. Burgess, K.; van der Donk, W.A. “On Hydroborations of Alkenes by Titanium Complexes”Tetrahedron Lett. 1993, 6817-6820.
6. Burgess, K.; van der Donk, W.A.; Westcott, S.A.; Marder, T.B.; Baker, R.T.; Calabrese, J.C. “Reactions of Catecholborane with Wilkinson’s Catalyst: Implications for the Transition Metal-Catalyzed Hydroboration of Alkenes” J. Am. Chem. Soc. 1992, 114, 9350-9359.
5. Burgess, K.; van der Donk, W.A.; Jarstfer, M.B.; Ohlmeyer, M.J. “Further Evidence for the Role of d.pi.-p.pi. Bonding in Rhodium-Mediated Hydroborations” J. Am. Chem. Soc. 1991, 113, 6139-6144.
4. Burgess, K.; van der Donk, W.A.; Kook, A.M. “On Deuterium-Labeling Studies for Probing Rhodium-Catalyzed Hydroboration Reactions” J. Org. Chem. 1991, 56, 2949-2951.
3. Burgess, K.; van der Donk, W.A.; Ohlmeyer, M.J. “Enantioselectivehydroborations Catalyzed by Rhodium(+1)-complexes” Tetrahedron Asymmetry 1991, 2, 613-621.

Undergraduate Research (Leiden University, the Netherlands)
2. Haanstra, W.G.; van der Donk, W.A.J.W.; Driessen, W.L.; Reedijk, J.; Wood, J.S.; Drew, M.G.B. “Unusual Behaviour of the Thioether Function of the Ligand 1,8-Bis(3,5-dimethyl-1-pyrazolyl)-3,6-dithiaoctane (bddo) towards Transition-metal Salts. X-ray Structures of a Green and a Red Modification of [Cu(bddo)Cl2]” J. Chem. Soc. Dalton Trans. 1990, 3123-3128.
1. Haanstra, W.G.; van der Donk, W.A.J.W.; Driessen, W.L.; Reedijk, J.; Wood, J.S.; Drew, M.G.B. “Coordination Behaviour of the Ligand 1,9-Bis(3,5-dimethyl-1-pyrazolyl)-3,7-dithianonane (bddn) towards First Row Transition Metals. X-ray Structure of [Cu(bddn)(H2O)](BF4)2” Inorg.Chim.Acta 1990, 176, 299-305.

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