Publications by Type


Yu Y, Zhang Q, van der Donk WA. Insights into the evolution of lanthipeptide biosynthesis. Protein Sci. 2013 Nov;22(11):1478-89. doi: 10.1002/pro.2358. Epub 2013 Sep 18. Review. PubMed PMID: 24038659; PubMed Central PMCID: PMC3831664.

Peck SC, van der Donk WA. Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. Curr Opin Chem Biol. 2013 Aug;17(4):580-8. doi: 10.1016/j.cbpa.2013.06.018. Epub 2013 Jul 17. Review. PubMed PMID: 23870698; PubMed Central PMCID: PMC3764496.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review. PubMed PMID: 23165928; PubMed Central PMCID: PMC3954855.

Knerr PJ, van der Donk WA. Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem. 2012;81:479-505. doi: 10.1146/annurev-biochem-060110-113521. Epub 2012 Mar 8. Review. PubMed PMID: 22404629.

Zhang Q, van der Donk WA, Liu W. Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res. 2012 Apr 17;45(4):555-64. doi: 10.1021/ar200202c. Epub 2011 Nov 18. Review. PubMed PMID: 22097883; PubMed Central PMCID: PMC3328197.

Velásquez JE, van der Donk WA. Genome mining for ribosomally synthesized natural products. Curr Opin Chem Biol. 2011 Feb;15(1):11-21. doi: 10.1016/j.cbpa.2010.10.027. Epub 2010 Nov 20. Review. PubMed PMID: 21095156; PubMed Central PMCID: PMC3090663.

van der Donk WA, Krebs C, Bollinger JM Jr. Substrate activation by iron superoxo intermediates. Curr Opin Struct Biol. 2010 Dec;20(6):673-83. doi: 10.1016/ Epub 2010 Oct 14. Review. PubMed PMID: 20951572; PubMed Central PMCID: PMC3030196.

Nair SK, van der Donk WA. Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin. Arch Biochem Biophys. 2011 Jan 1;505(1):13-21. doi: 10.1016/ Epub 2010 Sep 18. Review. PubMed PMID: 20854789; PubMed Central PMCID: PMC3040005.

Oman TJ, van der Donk WA. Follow the leader: the use of leader peptides to guide natural product biosynthesis. Nat Chem Biol. 2010 Jan;6(1):9-18. doi: 10.1038/nchembio.286. Review. PubMed PMID: 20016494; PubMed Central PMCID: PMC3799897.

Metcalf WW, van der Donk WA. Biosynthesis of phosphonic and phosphinic acid natural products. Annu Rev Biochem. 2009;78:65-94. doi: 10.1146/annurev.biochem.78.091707.100215. Review. PubMed PMID: 19489722; PubMed Central PMCID: PMC2729427.

Willey JM, van der Donk WA. Lantibiotics: peptides of diverse structure and function. Annu Rev Microbiol. 2007;61:477-501. Review. PubMed PMID: 17506681.

van der Donk WA. Rings, radicals, and regeneration: the early years of a bioorganic laboratory. J Org Chem. 2006 Dec 22;71(26):9561-71. Review. PubMed PMID: 17168571; PubMed Central PMCID: PMC2519235.

van der Donk WA. Lighting up the nascent cell wall. ACS Chem Biol. 2006 Aug 22;1(7):425-8. Review. PubMed PMID: 17168519.

Patton GC, van der Donk WA. New developments in lantibiotic biosynthesis and mode of action. Curr Opin Microbiol. 2005 Oct;8(5):543-51. Review. PubMed PMID: 16118063

Chatterjee C, Paul M, Xie L, van der Donk WA. Biosynthesis and mode of action of lantibiotics. Chem Rev. 2005 Feb;105(2):633-84. Review. PubMed PMID: 15700960.

Xie L, van der Donk WA. Post-translational modifications during lantibiotic biosynthesis. Curr Opin Chem Biol. 2004 Oct;8(5):498-507. Review. PubMed PMID: 15450492.

McGinley CM, van der Donk WA. Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids. Chem Commun (Camb). 2003 Dec 7;(23):2843-6. Review. PubMed PMID: 14680206.

Zhao H, van der Donk WA. Regeneration of cofactors for use in biocatalysis. Curr Opin Biotechnol. 2003 Dec;14(6):583-9. Review. PubMed PMID: 14662386.

van der Donk WA, Zhao H. Recent developments in pyridine nucleotide regeneration. Curr Opin Biotechnol. 2003 Aug;14(4):421-6. Review. PubMed PMID: 12943852.

Kulmacz RJ, van der Donk WA, Tsai AL. Comparison of the properties of prostaglandin H synthase-1 and -2. Prog Lipid Res. 2003 Sep;42(5):377-404. Review. PubMed PMID: 12814642.

van der Donk WA, Tsai AL, Kulmacz RJ. The cyclooxygenase reaction mechanism. Biochemistry. 2002 Dec 31;41(52):15451-8. Review. PubMed PMID: 12501173.

Gieselman MD, Zhu Y, Zhou H, Galonic D, van der Donk WA. Selenocysteine derivatives for chemoselective ligations. Chembiochem. 2002 Aug 2;3(8):709-16. Review. PubMed PMID: 12203969.

Pesavento RP, van der Donk WA. Tyrosyl radical cofactors. Adv Protein Chem. 2001;58:317-85. Review. PubMed PMID: 11665491.

Okeley NM, van der Donk WA. Novel cofactors via post-translational modifications of enzyme active sites. Chem Biol. 2000 Jul;7(7):R159-71. Review. Erratum in: Chem Biol 2001 Jan;8(1):97. PubMed PMID: 10903941.

Stubbe J, van der Donk WA. Ribonucleotide reductases: radical enzymes with suicidal tendencies. Chem Biol. 1995 Dec;2(12):793-801. Review. PubMed PMID: 8807812.


Zedu Huang, Kwo-Kwang A. Wang, Jaeheon Lee, Wilfred A. van der Donk. Biosynthesis of fosfazinomycin is a convergent process. Chem. Sci. 2015; 6, 1282-1287. doi: 10.1039/C4SC03095H.

Tang W, Jiménez-Osés G, Houk KN, van der Donk WA. Substrate control in stereoselective lanthionine biosynthesis. Nat Chem. 2015 Jan;7(1):57-64. doi: 10.1038/nchem.2113. Epub 2014 Nov 24. PubMed PMID: 25515891; PubMed Central PMCID: PMC4270103.

Thibodeaux CJ, Ha T, van der Donk WA. A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2. J Am Chem Soc. 2014 Dec 17;136(50):17513-29. doi: 10.1021/ja5089452. Epub 2014 Dec 4. PubMed PMID: 25409537.

Ortega MA, Hao Y, Zhang Q, Walker MC, van der Donk WA, Nair SK. Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB. Nature. 2014 Oct 26. doi: 10.1038/nature13888. [Epub ahead of print] PubMed PMID: 25363770.

Zeng M, van der Donk WA, Chen J. Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt. Mol Biol Cell. 2014 Dec 1;25(24):3954-61. doi: 10.1091/mbc.E14-01-0004. Epub 2014 Oct 1. PubMed PMID: 25273559; PubMed Central PMCID: PMC4244203.

Zhang Q, Yang X, Wang H, van der Donk WA. High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis. ACS Chem Biol. 2014 Nov 21;9(11):2686-94. doi: 10.1021/cb500622c. Epub 2014 Oct 2. PubMed PMID: 25244001;
PubMed Central PMCID: PMC4245175.

Zhang Q, Ortega M, Shi Y, Wang H, Melby JO, Tang W, Mitchell DA, van der Donk WA. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12031-6. doi: 10.1073/pnas.1406418111. Epub 2014 Aug 4. PubMed PMID: 25092299; PubMed Central PMCID: PMC4143002.

Huang Y, Reis ES, Knerr PJ, van der Donk WA, Ricklin D, Lambris JD. Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin. Chem Med Chem. 2014 Oct;9(10):2223-6. doi: 10.1002/cmdc.201402212. Epub 2014 Jul
23. PubMed PMID: 25056114; PubMed Central PMCID: PMC4177305.

Mukherjee S, van der Donk WA. Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM. J Am Chem Soc. 2014 Jul 23;136(29):10450-9. doi: 10.1021/ja504692v. Epub 2014 Jul 8. PubMed PMID: 24972336; PubMed Central PMCID: PMC4111213.

Ortega MA, Velásquez JE, Garg N, Zhang Q, Joyce RE, Nair SK, van der Donk WA. Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO. ACS Chem Biol. 2014 Aug 15;9(8):1718-25. doi: 10.1021/cb5002526. Epub 2014 Jun 6. PubMed PMID: 24866416; PubMed Central PMCID: PMC4136673.

Clark KM, Yu Y, van der Donk WA, Blackburn N, Lu Y. Modulating the Copper-Sulfur Interaction in Type 1 Blue Copper Azurin by Replacing Cys112 with Nonproteinogenic Homocysteine. Inorg Chem Front. 2014 Feb 1;1(2):153-158. PubMed PMID: 24707355; PubMed Central PMCID: PMC3972132.

Hung JE, Fogle EJ, Garg N, Chekan JR, Nair SK, van der Donk WA. Chemical rescue and inhibition studies to determine the role of Arg301 in phosphite dehydrogenase. PLoS One. 2014 Jan 31;9(1):e87134. doi: 10.1371/journal.pone.0087134. eCollection 2014. PubMed PMID: 24498026; PubMed Central PMCID: PMC3909101.

Garcia De Gonzalo CV, Zhu L, Oman TJ, van der Donk WA. NMR structure of the S-linked glycopeptide sublancin 168. ACS Chem Biol. 2014 Mar 21;9(3):796-801. doi: 10.1021/cb4008106. Epub 2014 Jan 17. PubMed PMID: 24405370; PubMed Central PMCID: PMC3985867.

Gao J, Ju KS, Yu X, Velásquez JE, Mukherjee S, Lee J, Zhao C, Evans BS, Doroghazi JR, Metcalf WW, van der Donk WA. Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angew Chem Int Ed Engl. 2014 Jan 27;53(5):1334-7. doi: 10.1002/anie.201308363. Epub 2013 Dec 27. PubMed PMID: 24376039; PubMed Central PMCID: PMC3927463.

Agarwal V, Peck SC, Chen JH, Borisova SA, Chekan JR, van der Donk WA, Nair SK. Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation. Chem Biol. 2014 Jan 16;21(1):125-35. doi: 10.1016/j.chembiol.2013.11.006. Epub 2013 Dec 19. PubMed PMID: 24361046.

Wang H, Oman TJ, Zhang R, Garcia De Gonzalo CV, Zhang Q, van der Donk WA. The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation. J Am Chem Soc. 2014 Jan 8;136(1):84-7. doi: 10.1021/ja411159k. Epub 2013 Dec 16. PubMed PMID: 24325644; PubMed Central PMCID: PMC3913795.

Garg N, Oman TJ, Andrew Wang TS, De Gonzalo CV, Walker S, van der Donk WA. Mode of action and structure-activity relationship studies of geobacillin I. J Antibiot (Tokyo). 2014 Jan;67(1):133-6. doi: 10.1038/ja.2013.112. Epub 2013 Oct 30. PubMed PMID: 24169799; PubMed Central PMCID: PMC4004768.

Bindman NA, van der Donk WA. A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization. J Am Chem Soc. 2013 Jul 17;135(28):10362-71. doi: 10.1021/ja4010706. Epub 2013 Jul 8. PubMed PMID: 23789944; PubMed Central PMCID: PMC3775354.

Bougioukou DJ, Mukherjee S, van der Donk WA. Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10952-7. doi: 10.1073/pnas.1303568110. Epub 2013 Jun 17. PubMed PMID: 23776232; PubMed Central PMCID: PMC3704017.

Yang X, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis. Chemistry. 2013 Jun 10;19(24):7662-77. doi: 10.1002/chem.201300401. Epub 2013 May 10. PubMed PMID: 23666908; PubMed Central PMCID: PMC3838977.

Knerr PJ, van der Donk WA. Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry. J Am Chem Soc. 2013 May 15;135(19):7094-7. doi: 10.1021/ja4014024. Epub 2013 May 3. PubMed PMID: 23621626; PubMed Central PMCID: PMC3736828.

Garg N, Salazar-Ocampo LM, van der Donk WA. In vitro activity of the nisin dehydratase NisB. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7258-63. doi: 10.1073/pnas.1222488110. Epub 2013 Apr 15. PubMed PMID: 23589847; PubMed Central PMCID: PMC3645518.

Peck SC, van der Donk WA. Biochemistry: Positive and radical. Nature. 2013 Apr 4;496(7443):34-5. doi: 10.1038/496034a. PubMed PMID: 23552937.

Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. ACS Chem Biol. 2013 May 17;8(5):908-13. doi: 10.1021/cb400102t. Epub 2013 Mar 13. PubMed PMID: 23474169; PubMed Central PMCID: PMC3657337.

Tang W, van der Donk WA. The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat Chem Biol. 2013 Mar;9(3):157-9. doi: 10.1038/nchembio.1162. Epub 2013 Jan 13. PubMed PMID: 23314913; PubMed Central PMCID: PMC3578037.

Thibodeaux CJ, van der Donk WA. Converging on a mechanism for choline degradation. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21184-5. doi: 10.1073/pnas.1219534110. Epub 2012 Dec 14. PubMed PMID: 23243142; PubMed Central PMCID: PMC3535664.

Zhang Q, Yu Y, Vélasquez JE, van der Donk WA. Evolution of lanthipeptide synthetases. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18361-6. doi: 10.1073/pnas.1210393109. Epub 2012 Oct 15. PubMed PMID: 23071302; PubMed Central PMCID: PMC3494888.

Shi Y, Bueno A, van der Donk WA. Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli. Chem Commun (Camb). 2012 Nov 18;48(89):10966-8. doi: 10.1039/c2cc36336d. PubMed PMID: 23034674; PubMed Central PMCID: PMC3485686.

Peck SC, Gao J, van der Donk WA. Discovery and biosynthesis of phosphonate and phosphinate natural products. Methods Enzymol. 2012;516:101-23. doi: 10.1016/B978-0-12-394291-3.00029-0. PubMed PMID: 23034226.

Thibodeaux GN, van der Donk WA. An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase. Chem Commun (Camb). 2012 Nov 7;48(86):10615-7. doi: 10.1039/c2cc34138g. PubMed PMID: 23001385; PubMed Central
PMCID: PMC3475617.

Cooke HA, Peck SC, Evans BS, van der Donk WA. Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase. J Am Chem Soc. 2012 Sep 26;134(38):15660-3. Epub 2012 Sep 13. PubMed PMID: 22957470; PubMed Central PMCID: PMC3458437.

Metcalf WW, Griffin BM, Cicchillo RM, Gao J, Janga SC, Cooke HA, Circello BT, Evans BS, Martens-Habbena W, Stahl DA, van der Donk WA. Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science. 2012 Aug 31;337(6098):1104-7. doi: 10.1126/science.1219875. PubMed PMID: 22936780; PubMed Central PMCID: PMC3466329.

Knerr PJ, Oman TJ, Garcia De Gonzalo CV, Lupoli TJ, Walker S, van der Donk WA. Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation. ACS Chem Biol. 2012 Nov 16;7(11):1791-5. doi: 10.1021/cb300372b. Epub 2012 Sep 4. PubMed PMID: 22920239;
PubMed Central PMCID: PMC3501146.

Peck SC, Kim SY, Evans BS, van der Donk WA. Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis. Med Chem Comm. 2012 Aug;3(8):967-970. PubMed PMID: 25400901; PubMed Central PMCID: PMC4231301.

Zhang Q, van der Donk WA. Catalytic promiscuity of a bacterial
α-N-methyltransferase. FEBS Lett. 2012 Sep 21;586(19):3391-7. doi: 10.1016/j.febslet.2012.07.050. Epub 2012 Jul 25. PubMed PMID: 22841713; PubMed Central PMCID: PMC3462432.

Wang H, van der Donk WA. Biosynthesis of the class III lantipeptide catenulipeptin. ACS Chem Biol. 2012 Sep 21;7(9):1529-35. Epub 2012 Jul 2. PubMed PMID: 22725258; PubMed Central PMCID: PMC3448297.

Kim SY, Ju KS, Metcalf WW, Evans BS, Kuzuyama T, van der Donk WA. Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. Antimicrob Agents Chemother. 2012 Aug;56(8):4175-83. doi: 10.1128/AAC.06478-11. Epub 2012 May 21. PubMed PMID: 22615277; PubMed Central PMCID: PMC3421606.

Tang W, van der Donk WA. Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry. 2012 May 29;51(21):4271-9. doi: 10.1021/bi300255s. Epub 2012 May 17. PubMed PMID: 22574919; PubMed Central PMCID: PMC3361976.

Zou Y, Zhang H, Brunzelle JS, Johannes TW, Woodyer R, Hung JE, Nair N, van der Donk WA, Zhao H, Nair SK. Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration. Biochemistry. 2012 May 29;51(21):4263-70. doi: 10.1021/bi2016926. Epub 2012 May 17. PubMed PMID: 22564171.

Hung JE, Fogle EJ, Christman HD, Johannes TW, Zhao H, Metcalf WW, van der Donk WA. Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase. Biochemistry. 2012 May 29;51(21):4254-62. doi: 10.1021/bi201691w. Epub 2012 May 17. PubMed PMID: 22564138; PubMed Central PMCID: PMC3361975.

Knerr PJ, van der Donk WA. Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X. J Am Chem Soc. 2012 May 9;134(18):7648-51. doi: 10.1021/ja302435y. Epub 2012 Apr 30. PubMed PMID: 22524291; PubMed Central PMCID: PMC3349288.

Oman TJ, Knerr PJ, Bindman NA, Velásquez JE, van der Donk WA. An engineered lantibiotic synthetase that does not require a leader peptide on its substrate. J Am Chem Soc. 2012 Apr 25;134(16):6952-5. doi: 10.1021/ja3017297. Epub 2012 Apr 11. PubMed PMID: 22480178; PubMed Central PMCID: PMC3350211.

Garg N, Tang W, Goto Y, Nair SK, van der Donk WA. Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5241-6. doi: 10.1073/pnas.1116815109. Epub 2012 Mar 19. PubMed PMID: 22431611; PubMed Central PMCID: PMC3325677.

Zhang Q, van der Donk WA. Answers to the carbon-phosphorus lyase conundrum. Chem Bio Chem. 2012 Mar 19;13(5):627-9. doi: 10.1002/cbic.201200020. Epub 2012 Feb 14. PubMed PMID: 22334536; PubMed Central PMCID: PMC3544170.

Agarwal V, Borisova SA, Metcalf WW, van der Donk WA, Nair SK. Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chem Biol. 2011 Oct 28;18(10):1230-40. doi: 10.1016/j.chembiol.2011.07.019. PubMed PMID: 22035792.

Oman TJ, Lupoli TJ, Wang TS, Kahne D, Walker S, van der Donk WA. Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry. J Am Chem Soc. 2011 Nov 9;133(44):17544-7. doi: 10.1021/ja206281k. Epub 2011 Oct 17. PubMed PMID: 22003874; PubMed Central PMCID: PMC3206492.

Wang H, van der Donk WA. Substrate selectivity of the sublancin S-glycosyltransferase. J Am Chem Soc. 2011 Oct 19;133(41):16394-7. doi: 10.1021/ja2075168. Epub 2011 Sep 21. PubMed PMID: 21910430; PubMed Central PMCID: PMC3191765.

DeSieno MA, van der Donk WA, Zhao H. Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ. Chem Commun (Camb). 2011 Sep 28;47(36):10025-7. doi: 10.1039/c1cc13597j. Epub 2011 Aug 10. PubMed PMID: 21829824; PubMed Central PMCID: PMC4091617.

Velásquez JE, Zhang X, van der Donk WA. Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. Chem Biol. 2011 Jul 29;18(7):857-67. doi: 10.1016/j.chembiol.2011.05.007. PubMed PMID: 21802007; PubMed Central PMCID: PMC3161514.

Ökesli A, Cooper LE, Fogle EJ, van der Donk WA. Nine post-translational modifications during the biosynthesis of cinnamycin. J Am Chem Soc. 2011 Aug 31;133(34):13753-60. doi: 10.1021/ja205783f. Epub 2011 Aug 10. PubMed PMID: 21770392; PubMed Central PMCID: PMC3163434.

Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA. Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase. Biochemistry. 2011 Aug 2;50(30):6598-605. doi: 10.1021/bi200804r. Epub 2011 Jul 8. PubMed PMID: 21711001; PubMed Central PMCID: PMC3143709.

Borisova SA, Christman HD, Metcalf ME, Zulkepli NA, Zhang JK, van der Donk WA, Metcalf WW. Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021. J Biol Chem. 2011 Jun 24;286(25):22283-90. doi: 10.1074/jbc.M111.237735. Epub 2011 May 4. PubMed PMID: 21543322; PubMed Central PMCID: PMC3121374.

Circello BT, Miller CG, Lee JH, van der Donk WA, Metcalf WW. The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica. Antimicrob Agents Chemother. 2011 Jul;55(7):3357-62. doi: 10.1128/AAC.01483-10. Epub 2011 May 2. PubMed PMID: 21537024; PubMed Central PMCID: PMC3122408.

Knerr PJ, Tzekou A, Ricklin D, Qu H, Chen H, van der Donk WA, Lambris JD. Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin. ACS Chem Biol. 2011 Jul 15;6(7):753-60. doi: 10.1021/cb2000378. Epub 2011 May 23. PubMed PMID: 21520911; PubMed Central PMCID: PMC3137721.

Gut IM, Blanke SR, van der Donk WA. Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin. ACS Chem Biol. 2011 Jul 15;6(7):744-52. doi: 10.1021/cb1004178. Epub 2011 May 5. PubMed PMID: 21517116; PubMed Central PMCID: PMC3178273.

Tsai AL, Wu G, Rogge CE, Lü JM, Peng S, van der Donk WA, Palmer G, Gerfen GJ, Kulmacz RJ. Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2. J Inorg Biochem. 2011 Mar;105(3):366-74. doi: 10.1016/j.jinorgbio.2010.11.012. Epub 2010 Nov 27. PubMed PMID: 21421123; PubMed Central PMCID: PMC3073652.

Lü JM, Rogge CE, Wu G, Kulmacz RJ, van der Donk WA, Tsai AL. Cyclooxygenase reaction mechanism of PGHS–evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping. J Inorg Biochem. 2011 Mar;105(3):356-65. doi: 10.1016/j.jinorgbio.2010.11.013. PubMed
PMID: 21403766; PubMed Central PMCID: PMC3053578.

Wu G, Lü JM, van der Donk WA, Kulmacz RJ, Tsai AL. Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects. J Inorg Biochem. 2011 Mar;105(3):382-90. doi: 10.1016/j.jinorgbio.2010.11.015. PubMed PMID: 21394223; PubMed Central PMCID: PMC3049311.

Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA. On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. J Am Chem Soc. 2011 Mar 30;133(12):4236-9. doi: 10.1021/ja1113326. Epub 2011 Mar 7. PubMed PMID: 21381767; PubMed Central PMCID: PMC3069692.

Gut IM, Tamilselvam B, Prouty AM, Stojkovic B, Czeschin S, van der Donk WA, Blanke SR. Bacillus anthracis spore interactions with mammalian cells: relationship between germination state and the outcome of in vitro. BMC Microbiol. 2011 Feb 28;11:46. doi: 10.1186/1471-2180-11-46. PubMed PMID: 21356113; PubMed Central PMCID: PMC3060849.

Goto Y, Okesli A, van der Donk WA. Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family. Biochemistry. 2011 Feb 8;50(5):891-8. doi: 10.1021/bi101750r. Epub 2011 Jan 13. PubMed PMID: 21229987; PubMed Central PMCID: PMC3031989.

Oman TJ, Boettcher JM, Wang H, Okalibe XN, van der Donk WA. Sublancin is not a lantibiotic but an S-linked glycopeptide. Nat Chem Biol. 2011 Feb;7(2):78-80. doi: 10.1038/nchembio.509. Epub 2011 Jan 2. PubMed PMID: 21196935; PubMed Central PMCID: PMC3060661.

Shi Y, Yang X, Garg N, van der Donk WA. Production of lantipeptides in Escherichia coli. J Am Chem Soc. 2011 Mar 2;133(8):2338-41. doi: 10.1021/ja109044r. Epub 2010 Nov 29. PubMed PMID: 21114289; PubMed Central PMCID: PMC3044485.

Bindman N, Merkx R, Koehler R, Herrman N, van der Donk WA. Photochemical cleavage of leader peptides. Chem Commun (Camb). 2010 Dec 21;46(47):8935-7. doi: 10.1039/c0cc02945a. Epub 2010 Nov 2. PubMed PMID: 21046030; PubMed Central PMCID: PMC3100556.

Lee JH, Bae B, Kuemin M, Circello BT, Metcalf WW, Nair SK, van der Donk WA. Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17557-62. doi: 10.1073/pnas.1006848107. Epub 2010 Sep 27. PubMed PMID: 20876132; PubMed Central PMCID: PMC2955109.

Kuemin M, van der Donk WA. Structure-activity relationships of the phosphonate antibiotic dehydrophos. Chem Commun (Camb). 2010 Nov 7;46(41):7694-6. doi: 10.1039/c0cc02958k. Epub 2010 Sep 27. PubMed PMID: 20871915; PubMed Central PMCID: PMC3109733.

Clark KM, Yu Y, Marshall NM, Sieracki NA, Nilges MJ, Blackburn NJ, van der Donk WA, Lu Y. Transforming a blue copper into a red copper protein: engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation. J Am Chem Soc. 2010 Jul 28;132(29):10093-101. doi: 10.1021/ja102632p. PubMed PMID: 20608676; PubMed Central PMCID: PMC2929572.

Li B, Sher D, Kelly L, Shi Y, Huang K, Knerr PJ, Joewono I, Rusch D, Chisholm SW, van der Donk WA. Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10430-5. doi: 10.1073/pnas.0913677107. Epub 2010 May 17. PubMed PMID: 20479271; PubMed Central PMCID: PMC2890784.

Circello BT, Eliot AC, Lee JH, van der Donk WA, Metcalf WW. Molecular cloningand heterologous expression of the dehydrophos biosynthetic gene cluster. Chem Biol. 2010 Apr 23;17(4):402-11. doi: 10.1016/j.chembiol.2010.03.007. PubMed PMID: 20416511; PubMed Central PMCID: PMC2888486.

Goto Y, Li B, Claesen J, Shi Y, Bibb MJ, van der Donk WA. Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol. 2010 Mar 23;8(3):e1000339. doi: 10.1371/journal.pbio.1000339. PubMed PMID: 20351769; PubMed Central PMCID: PMC2843593.

Borisova SA, Circello BT, Zhang JK, van der Donk WA, Metcalf WW. Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633. Chem Biol. 2010 Jan 29;17(1):28-37. doi: 10.1016/j.chembiol.2009.11.017. PubMed PMID: 20142038; PubMed Central PMCID: PMC2819989.

Whitteck JT, Cicchillo RM, van der Donk WA. Hydroperoxylation by hydroxyethylphosphonate dioxygenase. J Am Chem Soc. 2009 Nov 11;131(44):16225-32. doi: 10.1021/ja906238r. PubMed PMID: 19839620; PubMed Central PMCID: PMC2773148.

Oman TJ, van der Donk WA. Insights into the mode of action of the two-peptide lantibiotic haloduracin. ACS Chem Biol. 2009 Oct 16;4(10):865-74. doi: 10.1021/cb900194x. PubMed PMID: 19678697; PubMed Central PMCID: PMC2812937.

Lee MV, Ihnken LA, You YO, McClerren AL, van der Donk WA, Kelleher NL. Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J Am Chem Soc. 2009 Sep 2;131(34):12258-64. doi: 10.1021/ja9033507. PubMed PMID: 19663480; PubMed Central
PMCID: PMC2738757.

Levengood MR, Knerr PJ, Oman TJ, van der Donk WA. In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids. J Am Chem Soc. 2009 Sep 2;131(34):12024-5. doi: 10.1021/ja903239s. PubMed PMID: 19655738; PubMed Central PMCID: PMC2732204.

Wecksler AT, Kenyon V, Garcia NK, Deschamps JD, van der Donk WA, Holman TR. Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. Biochemistry. 2009 Sep 15;48(36):8721-30. doi: 10.1021/bi9009242. PubMed PMID: 19645454; PubMed Central PMCID: PMC2746553.

Zhang X, van der Donk WA. Using expressed protein ligation to probe the substrate specificity of lantibiotic synthetases. Methods Enzymol. 2009;462:117-34. doi: 10.1016/S0076-6879(09)62006-1. PubMed PMID: 19632472.

Clark KM, van der Donk WA, Lu Y. Expressed protein ligation for
metalloprotein design and engineering. Methods Enzymol. 2009;462:97-115. doi: 10.1016/S0076-6879(09)62005-X. PubMed PMID: 19632471; PubMed Central PMCID: PMC2780537.

Cicchillo RM, Zhang H, Blodgett JA, Whitteck JT, Li G, Nair SK, van der Donk WA, Metcalf WW. An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis. Nature. 2009 Jun 11;459(7248):871-4. doi: 10.1038/nature07972. PubMed PMID: 19516340; PubMed Central PMCID: PMC2874955.

Wecksler AT, Jacquot C, van der Donk WA, Holman TR. Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. Biochemistry. 2009 Jul 7;48(26):6259-67. doi: 10.1021/bi802332j. PubMed PMID: 19469483; PubMed Central PMCID: PMC2935259.

Lee JH, Evans BS, Li G, Kelleher NL, van der Donk WA. In vitro
characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis. Biochemistry. 2009 Jun 16;48(23):5054-6. doi: 10.1021/bi900164d. PubMed PMID: 19432442; PubMed Central PMCID: PMC2709985.

Li B, Cooper LE, van der Donk WA. Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol. 2009;458:533-58. doi: 10.1016/S0076-6879(09)04821-6. PubMed PMID: 19374997.

You YO, Levengood MR, Ihnken LA, Knowlton AK, van der Donk WA. Lacticin 481 synthetase as a general serine/threonine kinase. ACS Chem Biol. 2009 May 15;4(5):379-85. doi: 10.1021/cb800309v. PubMed PMID: 19292452; PubMed Central PMCID: PMC2709986.

Levengood MR, Kerwood CC, Chatterjee C, van der Donk WA. Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chem Bio Chem. 2009 Mar 23;10(5):911-9. doi: 10.1002/cbic.200800752. PubMed PMID: 19222036; PubMed Central PMCID: PMC2737179.

Barry AN, Clark KM, Otoikhian A, van der Donk WA, Blackburn NJ. Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase. Biochemistry. 2008 Dec 9;47(49):13074-83. doi: 10.1021/bi801438g. PubMed PMID: 19007184; PubMed Central PMCID: PMC2645929.

Jacquot C, McGinley CM, Plata E, Holman TR, van der Donk WA. Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Org Biomol Chem. 2008 Nov 21;6(22):4242-52. doi: 10.1039/b808003h. Epub 2008 Sep 30. PubMed PMID: 18972057; PubMed Central PMCID: PMC2883171.

Cooper LE, McClerren AL, Chary A, van der Donk WA. Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chem Biol. 2008 Oct 20;15(10):1035-45. doi: 10.1016/j.chembiol.2008.07.020. PubMed PMID: 18940665; PubMed Central PMCID: PMC2633096.

Gut IM, Prouty AM, Ballard JD, van der Donk WA, Blanke SR. Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrob Agents Chemother. 2008 Dec;52(12):4281-8. doi: 10.1128/AAC.00625-08. Epub 2008 Sep 22. PubMed PMID: 18809941; PubMed Central PMCID: PMC2592879.

Jacquot C, Peng S, van der Donk WA. Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5959-62. doi: 10.1016/j.bmcl.2008.08.108. Epub 2008 Aug 31. PubMed PMID: 18793849; PubMed Central PMCID: PMC2652760.

Patton GC, Paul M, Cooper LE, Chatterjee C, van der Donk WA. The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry. 2008 Jul 15;47(28):7342-51. doi: 10.1021/bi800277d. Epub 2008 Jun 21. PubMed PMID: 18570437; PubMed Central PMCID: PMC2574844.

Furgerson Ihnken LA, Chatterjee C, van der Donk WA. In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry. 2008 Jul 15;47(28):7352-63. doi: 10.1021/bi800278n. Epub 2008 Jun 21. PubMed PMID: 18570436; PubMed Central PMCID: PMC2574596.

Jacquot C, Wecksler AT, McGinley CM, Segraves EN, Holman TR, van der Donk WA. Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry. 2008 Jul 8;47(27):7295-303. doi: 10.1021/bi800308q. Epub 2008 Jun 12. PubMed PMID: 18547056; PubMed Central PMCID: PMC2574664.

Shao Z, Blodgett JA, Circello BT, Eliot AC, Woodyer R, Li G, van der Donk WA, Metcalf WW, Zhao H. Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. J Biol Chem. 2008 Aug 22;283(34):23161-8. doi: 10.1074/jbc.M801788200. Epub 2008 Jun 10. PubMed PMID: 18544530; PubMed Central PMCID: PMC2516978.

Levengood MR, van der Donk WA. Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett. 2008 May 15;18(10):3025-8. doi: 10.1016/j.bmcl.2008.01.062. Epub 2008 Jan 19. PubMed PMID: 18294843; PubMed Central PMCID: PMC2452991.

Whitteck JT, Ni W, Griffin BM, Eliot AC, Thomas PM, Kelleher NL, Metcalf WW, van der Donk WA. Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angew Chem Int Ed Engl. 2007;46(47):9089-92. PubMed PMID: 17990255.

Fogle EJ, van der Donk WA. Pre-steady-state studies of phosphite dehydrogenase demonstrate that hydride transfer is fully rate limiting. Biochemistry. 2007 Nov 13;46(45):13101-8. Epub 2007 Oct 20. PubMed PMID: 17949110; PubMed Central PMCID: PMC2517116.

Levengood MR, Patton GC, van der Donk WA. The leader peptide is not required for post-translational modification by lacticin 481 synthetase. J Am Chem Soc. 2007 Aug 29;129(34):10314-5. Epub 2007 Aug 4. PubMed PMID: 17676843; PubMed Central PMCID: PMC2492579.

Zhang X, Ni W, van der Donk WA. On the regioselectivity of thioether formation by lacticin 481 synthetase. Org Lett. 2007 Aug 16;9(17):3343-6. Epub 2007 Jul 25. PubMed PMID: 17650008; PubMed Central PMCID: PMC2517117.

Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW. Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol. 2007 Aug;3(8):480-5. Epub 2007 Jul 15. PubMed PMID: 17632514.

Li B, van der Donk WA. Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J Biol Chem. 2007 Jul 20;282(29):21169-75. Epub 2007 May 19. PubMed PMID: 17513866.

McGinley CM, Jacquot C, van der Donk WA. Synthesis of 7-thiaarachidonic acid as a mechanistic probe of prostaglandin H synthase-2. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4049-52. Epub 2007 Apr 27. PubMed PMID: 17485208; PubMed Central PMCID: PMC2040112.

Paul M, Patton GC, van der Donk WA. Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry. 2007 May 29;46(21):6268-76. Epub 2007 May 5. PubMed PMID: 17480057; PubMed Central PMCID: PMC2517114.

You YO, van der Donk WA. Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry. 2007 May 22;46(20):5991-6000. Epub 2007 Apr 25. PubMed PMID: 17455908; PubMed Central PMCID: PMC2517115.

Levengood MR, van der Donk WA. Dehydroalanine-containing peptides: preparation from phenylselenocysteine and utility in convergent ligation strategies. Nat Protoc. 2006;1(6):3001-10. PubMed PMID: 17406561.

Zhang X, van der Donk WA. On the substrate specificity of dehydration by lacticin 481 synthetase. J Am Chem Soc. 2007 Feb 28;129(8):2212-3. Epub 2007 Feb 1. PubMed PMID: 17266311; PubMed Central PMCID: PMC2517113.

Woodyer RD, Li G, Zhao H, van der Donk WA. New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chem Commun (Camb). 2007 Jan 28;(4):359-61. Epub 2006 Nov 23. PubMed PMID: 17220970.

Li G, van der Donk WA. Efficient synthesis of suitably protected beta-difluoroalanine and gamma-difluorothreonine from L-ascorbic acid. Org Lett. 2007 Jan 4;9(1):41-4. PubMed PMID: 17192080; PubMed Central PMCID: PMC2593874.

Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H. Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol. 2006 Nov;13(11):1171-82. PubMed PMID: 17113999.

McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA. Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17243-8. Epub 2006 Nov 3. PubMed PMID: 17085596; PubMed Central PMCID: PMC1859917.

Chatterjee C, Patton GC, Cooper L, Paul M, van der Donk WA. Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chem Biol. 2006 Oct;13(10):1109-17. PubMed PMID: 17052615.

Liu W, Wang LH, Fabian P, Hayashi Y, McGinley CM, van der Donk WA, Kulmacz RJ. Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function. Plant Physiol Biochem. 2006 May-Jun;44(5-6):284-93. Epub 2006 Jun 21. PubMed PMID: 16889973.

Pesavento RP, Pratt DA, Jeffers J, van der Donk WA. Model studies of the Cu(B) site of cytochrome c oxidase utilizing a Zn(II) complex containing an imidazole-phenol cross-linked ligand. Dalton Trans. 2006 Jul 21;(27):3326-37. Epub 2006 Apr 20. PubMed PMID: 16820845.

Woodyer R, van der Donk WA, Zhao H. Optimizing a biocatalyst for improved NAD(P)H regeneration: directed evolution of phosphite dehydrogenase. Comb Chem High Throughput Screen. 2006 May;9(4):237-45. PubMed PMID: 16724915.

McGinley CM, van der Donk WA. Synthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabel. J Labelled Comp Radiopharm. 2006 May 17;49(6):545-558. PubMed PMID: 20414469; PubMed Central PMCID: PMC2857661.

Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK. Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science. 2006 Mar 10;311(5766):1464-7. PubMed PMID: 16527981.

Miller LM, Chatterjee C, van der Donk WA, Kelleher NL. The dehydratase activity of lacticin 481 synthetase is highly processive. J Am Chem Soc. 2006 Feb 8;128(5):1420-1. PubMed PMID: 16448091; PubMed Central PMCID: PMC2532561.

Pratt DA, van der Donk WA. On the role of alkylcobalamins in the vitamin B12-catalyzed reductive dehalogenation of perchloroethylene and trichloroethylene. Chem Commun (Camb). 2006 Feb 7;(5):558-60. Epub 2005 Dec 20. PubMed PMID: 16432582.

Chatterjee C, Miller LM, Leung YL, Xie L, Yi M, Kelleher NL, van der Donk WA. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc. 2005 Nov 9;127(44):15332-3. PubMed PMID: 16262372.

Zhang X, Ni W, van der Donk WA. Synthesis of nonproteinogenic amino acids to probe lantibiotic biosynthesis. J Org Chem. 2005 Aug 19;70(17):6685-92. PubMed PMID: 16095288; PubMed Central PMCID: PMC2525736.

Woodyer R, Zhao H, van der Donk WA. Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration. FEBS J. 2005 Aug;272(15):3816-27. PubMed PMID: 16045753.

Pratt DA, Pesavento RP, van der Donk WA. Model studies of the histidine-tyrosine cross-link in cytochrome C oxidase reveal the flexible substituent effect of the imidazole moiety. Org Lett. 2005 Jun 23;7(13):2735-8. PubMed PMID: 15957934; PubMed Central PMCID: PMC2857394.

Galonić DP, Ide ND, van der Donk WA, Gin DY. Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification. J Am Chem Soc. 2005 May 25;127(20):7359-69. PubMed PMID: 15898784.

Relyea HA, Vrtis JM, Woodyer R, Rimkus SA, van der Donk WA. Inhibition and pH dependence of phosphite dehydrogenase. Biochemistry. 2005 May 3;44(17):6640-9. PubMed PMID: 15850397.

Woodyer R, Wheatley JL, Relyea HA, Rimkus S, van der Donk WA. Site-directed mutagenesis of active site residues of phosphite dehydrogenase. Biochemistry. 2005 Mar 29;44(12):4765-74. PubMed PMID: 15779903.

Woodyer R, Simurdiak M, van der Donk WA, Zhao H. Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa. Appl Environ Microbiol. 2005 Mar;71(3):1642-7. PubMed PMID: 15746370; PubMed Central PMCID: PMC1065158.

McCauley KM, Pratt DA, Wilson SR, Shey J, Burkey TJ, van der Donk WA. Properties and reactivity of chlorovinylcobalamin and vinylcobalamin and their implications for vitamin B12-catalyzed reductive dechlorination of chlorinated alkenes. J Am Chem Soc. 2005 Feb 2;127(4):1126-36. PubMed PMID: 15669852.

Pratt DA, van der Donk WA. Theoretical investigations into the intermediacy of chlorinated vinylcobalamins in the reductive dehalogenation of chlorinated ethylenes. J Am Chem Soc. 2005 Jan 12;127(1):384-96. PubMed PMID: 15631489.

Galonić DP, van der Donk WA, Gin DY. Site-selective conjugation of thiols with aziridine-2-carboxylic acid-containing peptides. J Am Chem Soc. 2004 Oct 13;126(40):12712-3. PubMed PMID: 15469231.

Peng S, van der Donk WA. An unusual isotope effect on substrate inhibition in the oxidation of arachidonic acid by lipoxygenase. J Am Chem Soc. 2003 Jul 30;125(30):8988-9. PubMed PMID: 15369335.

Ralle M, Berry SM, Nilges MJ, Gieselman MD, van der Donk WA, Lu Y, Blackburn NJ. The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. J Am Chem Soc. 2004 Jun 16;126(23):7244-56. PubMed PMID: 15186162.

Xie L, Miller LM, Chatterjee C, Averin O, Kelleher NL, van der Donk WA. Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science. 2004 Jan 30;303(5658):679-81. PubMed PMID: 14752162.

Peng S, McGinley CM, van der Donk WA. Synthesis of site-specifically labeled arachidonic acids as mechanistic probes for prostaglandin H synthase. Org Lett. 2004 Feb 5;6(3):349-52. PubMed PMID: 14748590.

Galonić DP, Van Der Donk WA, Gin DY. Oligosaccharide-peptide ligation of glycosyl thiolates with dehydropeptides: synthesis of S-linked mucin-related glycopeptide conjugates. Chemistry. 2003 Dec 15;9(24):5997-6006. PubMed PMID: 14679512.

Okeley NM, Paul M, Stasser JP, Blackburn N, van der Donk WA. SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry. 2003 Nov 25;42(46):13613-24. PubMed PMID: 14622008.

Zhou H, Schmidt DM, Gerlt JA, van der Donk WA. Chemical and enzymatic synthesis of fluorinated-dehydroalanine-containing peptides. Chem Bio Chem. 2003 Nov 7;4(11):1206-15. PubMed PMID: 14613113.

Zhu Y, Gieselman MD, Zhou H, Averin O, van der Donk WA. Biomimetic studies on the mechanism of stereoselective lanthionine formation. Org Biomol Chem. 2003 Oct 7;1(19):3304-15. PubMed PMID: 14584794.

Woodyer R, van der Donk WA, Zhao H. Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. Biochemistry. 2003 Oct 14;42(40):11604-14. PubMed PMID: 14529270.

McCauley KM, Wilson SR, van der Donk WA. Characterization of chlorovinylcobalamin, a putative intermediate in reductive degradation of chlorinated ethylenes. J Am Chem Soc. 2003 Apr 16;125(15):4410-1. PubMed PMID: 12683797.

McCauley KM, Wilson SR, van der Donk WA. Dichloroacetylene is not the precursor to dichlorinated vinylcobaloxime and vinylcobalamin in cobalt catalyzed dechlorination of perchloro- and trichloroethylene. Inorg Chem. 2002 Nov 4;41(22):5844-8. PubMed PMID: 12401092.

Vrtis JM, White AK, Metcalf WW, van der Donk WA. Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme. Angew Chem Int Ed Engl. 2002 Sep 2;41(17):3257-9. PubMed PMID: 12207407.

Peng S, Okeley NM, Tsai AL, Wu G, Kulmacz RJ, van der Donk WA. Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. J Am Chem Soc. 2002 Sep 11;124(36):10785-96. PubMed PMID: 12207535.

Tsai AL, Palmer G, Wu G, Peng S, Okeley NM, van der Donk WA, Kulmacz RJ. Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2. J Biol Chem. 2002 Oct 11;277(41):38311-21. Epub 2002 Aug 6. PubMed PMID: 12167656.

Xie L, Chatterjee C, Balsara R, Okeley NM, van der Donk WA. Heterologous expression and purification of SpaB involved in subtilin biosynthesis. Biochem Biophys Res Commun. 2002 Jul 26;295(4):952-7. PubMed PMID: 12127987.

Zhou H, van der Donk WA. Biomimetic stereoselective formation of methyllanthionine. Org Lett. 2002 Apr 18;4(8):1335-8. PubMed PMID: 11950356.

Berry SM, Gieselman MD, Nilges MJ, van Der Donk WA, Lu Y. An engineered azurin variant containing a selenocysteine copper ligand. J Am Chem Soc. 2002 Mar 13;124(10):2084-5. PubMed PMID: 11878940.

Shey J, McGinley CM, McCauley KM, Dearth AS, Young BT, van der Donk WA. Mechanistic investigation of a novel vitamin B(12)-catalyzed carbon [bond] carbon bond forming reaction, the reductive dimerization of arylalkenes. J Org Chem. 2002 Feb 8;67(3):837-46. PubMed PMID: 11856027.

Stubbe J, van Der Donk WA. Protein Radicals in Enzyme Catalysis. Chem. Rev. 1998, 98, 705minus sign762. Chem Rev. 1998 Nov 5;98(7):2661-2662. PubMed PMID: 11848974.

Stubbe J, van Der Donk WA. Protein Radicals in Enzyme Catalysis. Chem Rev. 1998 Apr 2;98(2):705-762. PubMed PMID: 11848913.

McCauley KM, Wilson SR, van der Donk WA. Synthesis and characterization of chlorinated alkenylcobaloximes to probe the mechanism of vitamin B(12)-catalyzed dechlorination of priority pollutants. Inorg Chem. 2002 Jan 28;41(2):393-404. PubMed PMID: 11800630.

Xie L, van der Donk WA. Homemade cofactors: self-processing in galactose oxidase. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12863-5. PubMed PMID: 11698675; PubMed Central PMCID: PMC60785.

Peng S, Okeley NM, Tsai AL, Wu G, Kulmacz RJ, van der Donk WA. Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2. J Am Chem Soc. 2001 Apr 18;123(15):3609-10. PubMed PMID: 11472139.

Vrtis JM, White AK, Metcalf WW, van der Donk WA. Phosphite dehydrogenase: an unusual phosphoryl transfer reaction. J Am Chem Soc. 2001 Mar 21;123(11):2672-3. PubMed PMID: 11456941.

Gieselman MD, Xie L, van Der Donk WA. Synthesis of a selenocysteine-containing peptide by native chemical ligation. Org Lett. 2001 May 3;3(9):1331-4. PubMed PMID: 11348227.

Zhu Y, van der Donk WA. Convergent synthesis of peptide conjugates using dehydroalanines for chemoselective ligations. Org Lett. 2001 Apr 19;3(8):1189-92. PubMed PMID: 11348191.

Zhou H, van der Donk WA. Synthesis of 2-amino-3-fluoroacrylic acid containing peptides. Org Lett. 2001 Feb 22;3(4):593-6. PubMed PMID: 11178833.

Okeley NM, Zhu Y, van Der Donk WA. Facile chemoselective synthesis of dehydroalanine-containing peptides. Org Lett. 2000 Nov 16;2(23):3603-6. PubMed PMID: 11073655.

van der Donk WA, Yu G, Pérez L, Sanchez RJ, Stubbe J, Samano V, Robins MJ. Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5′-diphosphate. Biochemistry. 1998 May 5;37(18):6419-26. PubMed PMID: 9572859.

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Li B, Cooper LE, van der Donk WA. Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods Enzymol. 2009;458:533-58. doi: 10.1016/S0076-6879(09)04821-6. PubMed PMID: 19374997.

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